Generation of a monkey with MECP2 mutations by TALEN-based gene targeting
Abstract
Gene editing in model organisms has provided critical insights into brain development and diseases. Here, we report the generation of a cynomolgus monkey (Macaca fascicularis) carrying MECP2 mutations using transcription activator-like effector nucleases (TALENs)-mediated gene targeting. After injecting TALENs mRNA into monkey zygotes achieved by in vitro fertilization and embryo transplantation into surrogate monkeys, we obtained one male...
Paper Details
Title
Generation of a monkey with MECP2 mutations by TALEN-based gene targeting
Published Date
May 16, 2014
Journal
Volume
30
Issue
3
Pages
381 - 386
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