Original paper
4-HNE Increases Intracellular ADMA Levels in Cultured HUVECs: Evidence for miR-21-Dependent Mechanisms
Abstract
To investigate whether 4-hydroxynonenal (4-HNE) regulates asymmetric dimethylarginine (ADMA) metabolism through pathway independent of direct adduct formation with ADMA metabolizing enzyme and the involvement of microRNA (miRNA) miR-21 in human umbilical venous endothelial cells (HUVECs).Cultured HUVECs were treated with 4-HNE (at concentrations of 1, 5, and 10 µM, respectively) or 1‰ DMSO (vehicle control) for 24 h. MiR-21 inhibitor (final...
Paper Details
Title
4-HNE Increases Intracellular ADMA Levels in Cultured HUVECs: Evidence for miR-21-Dependent Mechanisms
Published Date
May 22, 2013
Journal
Volume
8
Issue
5
Pages
e64148 - e64148
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Notes
History