Communicable Diseases Prioritized for Surveillance and Epidemiological Research: Results of a Standardized Prioritization Procedure in Germany, 2011

Published on Oct 4, 2011in PLOS ONE2.78
· DOI :10.1371/journal.pone.0025691
Yanina Balabanova28
Estimated H-index: 28
(RKI: Robert Koch Institute),
Andreas Gilsdorf13
Estimated H-index: 13
(RKI: Robert Koch Institute)
+ 18 AuthorsGérard Krause32
Estimated H-index: 32
(RKI: Robert Koch Institute)
Introduction: To establish strategic priorities for the German national public health institute (RKI) and guide the institute’s mid-term strategic decisions, we prioritized infectious pathogens in accordance with their importance for national surveillance and epidemiological research. Methods: We used the Delphi process with internal (RKI) and external experts and a metric-consensus approach to score pathogens according to ten three-tiered criteria. Additional experts were invited to weight each criterion, leading to the calculation of a median weight by which each score was multiplied. We ranked the pathogens according to the total weighted score and divided them into four priority groups. Results: 127 pathogens were scored. Eighty-six experts participated in the weighting; ‘‘Case fatality rate’’ was rated as the most important criterion. Twenty-six pathogens were ranked in the highest priority group; among those were pathogens with internationally recognised importance (e.g., Human Immunodeficiency Virus, Mycobacterium tuberculosis, Influenza virus, Hepatitis C virus, Neisseria meningitides), pathogens frequently causing large outbreaks (e.g., Campylobacter spp.), and nosocomial pathogens associated with antimicrobial resistance. Other pathogens in the highest priority group included Helicobacter pylori, Respiratory Syncytial Virus, Varicella zoster virus and Hantavirus. Discussion: While several pathogens from the highest priority group already have a high profile in national and international health policy documents, high scores for other pathogens (e.g., Helicobacter pylori, Respiratory syncytial virus or Hantavirus) indicate a possible under-recognised importance within the current German public health framework. A process to strengthen respective surveillance systems and research has been started. The prioritization methodology has worked well; its modular structure makes it potentially useful for other settings.
  • References (24)
  • Citations (71)
Published on Jan 1, 2012in Indian Journal of Medical Research1.25
D Behera1
Estimated H-index: 1
Published on Jul 15, 2011
Rebecca Katz13
Estimated H-index: 13
The Revised International Health Regulations is binding upon all Member States of the World Health Organization, and requires nations to have core capabilities to detect, notify and respond to public health emergencies of international concern. Keywords: International Health Regulations; World Health Organization; Infectious diseases; disease surveillance; health security
Published on May 5, 2011in Eurosurveillance7.42
Andreas Gilsdorf13
Estimated H-index: 13
(RKI: Robert Koch Institute),
Gérard Krause32
Estimated H-index: 32
(RKI: Robert Koch Institute)
In 2004, the German public health institute, the Robert Koch Institute (RKI), prioritised pathogens by public health criteria and presented the methodology and findings. In order to further improve the methodology, the RKI invited experts to give feedback on this via a structured web-based questionnaire. The survey was completed by 72 participants during 15 July 2008 to 15 January 2009. Prioritisation of pathogens was considered as useful for public health purposes by 68 participants and for bot...
Published on Jan 1, 2011in Journal of Gastroenterology and Hepatology3.63
Victoria P. Tan13
Estimated H-index: 13
(HKU: University of Hong Kong),
Benjamin C.Y. Wong54
Estimated H-index: 54
(HKU: University of Hong Kong)
Since its' introduction by Warren and Marshall 27 years ago, Helicobacter pylori (HP) has become the linchpin in our understanding of important gastric conditions including gastritis, intestinal metaplasia (IM), gastric/duodenal ulcers (GU/DU), Mucosal Associated Lymphoid Tumour (MALToma) and gastric cancer. Initially named Campylobacter pyloridis, it was re-named HP when biochemical and genetic characterization of the organism showed that it was not a member of the Campylobacter genus. The find...
Published on Dec 1, 2010in Journal of Pediatric Nursing
Susan Miller1
Estimated H-index: 1
Respiratory syncytial virus (RSV) is a significant health issue. Nearly all children contract RSV by 3 years of age. This virus causes mild cold-like symptoms in older children and adults. However, in infants and toddlers, it causes serious lower respiratory tract infections. Recovery from RSV can be lengthy, and caring for an unwell child can become a burden for a family. Prevention plans for those children that are at highest risk have been helpful in reducing the incidence of RSV. The America...
Published on Dec 1, 2010in Health Research Policy and Systems2.22
Roderik F. Viergever12
Estimated H-index: 12
(WHO: World Health Organization),
Sylvie Olifson5
Estimated H-index: 5
(Global Forum for Health Research)
+ 1 AuthorsRobert F Terry11
Estimated H-index: 11
(WHO: World Health Organization)
Health research priority setting processes assist researchers and policymakers in effectively targeting research that has the greatest potential public health benefit. Many different approaches to health research prioritization exist, but there is no agreement on what might constitute best practice. Moreover, because of the many different contexts for which priorities can be set, attempting to produce one best practice is in fact not appropriate, as the optimal approach varies per exercise. Ther...
Published on Apr 1, 2010in Eurosurveillance7.42
Anette Siedler24
Estimated H-index: 24
(RKI: Robert Koch Institute),
U Arndt1
Estimated H-index: 1
(Green Cross International)
Routine varicella vaccination with one dose for children of 11 to 14 months was recommended in Germany in 2004 to reduce disease incidence and severe complications. A country-wide varicella sentinel surveillance system was initiated in 2005 to detect trends of disease frequency and vaccine uptake and to evaluate the vaccination programme. A convenient sample of about 1,000 paediatricians and general practitioners was recruited to report on a monthly basis on varicella cases by age groups seen in...
Silvina Berra17
Estimated H-index: 17
Emília Sánchez13
Estimated H-index: 13
+ 3 AuthorsM. Aguilar-Pérez15
Estimated H-index: 15
(University of Girona)
Objectives: The objectives of this study is to review the set of criteria of the Institute of Medicine (IOM) for priority-setting in research with addition of new criteria if necessary, and to develop and evaluate the reliability and validity of the final priority score. Methods: Based on the evaluation of 199 research topics, forty-five experts identified additional criteria for priority-setting, rated their relevance, and ranked and weighted them in a three-round modified Delphi technique. A f...
Published on Dec 1, 2009in BMC Health Services Research1.93
Shannon L Sibbald1
Estimated H-index: 1
(U of T: University of Toronto),
Peter Singer78
Estimated H-index: 78
+ 1 AuthorsDouglas K. Martin38
Estimated H-index: 38
(U of T: University of Toronto)
Background The sustainability of healthcare systems worldwide is threatened by a growing demand for services and expensive innovative technologies. Decision makers struggle in this environment to set priorities appropriately, particularly because they lack consensus about which values should guide their decisions. One way to approach this problem is to determine what all relevant stakeholders understand successful priority setting to mean. The goal of this research was to develop a conceptual fr...
Published on Apr 1, 2009in Indian Journal of Medical Research1.25
Abdul Ghaffar1
Estimated H-index: 1
Methods: The construct and design of the CAM is explained along with different steps needed, including planning and organization of a priority-setting exercise and how it could be applied in different settings. Results: The application of the CAM are described by using three examples. The first concerns setting research priorities for a global programme, the second describes application at the country level and the third setting research priorities for diseases. Interpretation & conclusions: Eff...
Cited By71
Published on 2019in F1000Research
Burkhard Tümmler62
Estimated H-index: 62
(MHH: Hannover Medical School)
Infections with Pseudomonas aeruginosa have been marked with the highest priority for surveillance and epidemiological research on the basis of parameters such as incidence, case fatality rates, chronicity of illness, available options for prevention and treatment, health-care utilization, and societal impact. P. aeruginosa is one of the six ESKAPE pathogens that are the major cause of nosocomial infections and are a global threat because of their capacity to become increasingly resistant to all...
Gilberto Montibeller13
Estimated H-index: 13
(Lboro: Loughborough University),
Pratik Patel , Victor J. Del Rio Vilas2
Estimated H-index: 2
(University of Surrey)
Abstract Multi-criteria assessments are increasingly being employed in the prioritisation of health threats, supporting decision processes related to health risk management. The use of multi-criteria analysis in this context is welcome, as it facilitates the consideration of multiple impacts of health threats, it can encompass the use of expert judgment to complement and amalgamate the evidence available, and it permits the modelling of policy makers’ priorities. However, these assessments often...
Published on May 1, 2019in The Lancet Respiratory Medicine22.99
Anne Paschke (German Institute of Global and Area Studies), Ulrich E Schaible , Wolfgang Hein9
Estimated H-index: 9
(German Institute of Global and Area Studies)
Published on Dec 1, 2018in BMC Medical Research Methodology2.51
Thomas Jaenisch16
Estimated H-index: 16
(University Hospital Heidelberg),
Kim Hendrickx3
Estimated H-index: 3
(University of Liège)
+ 17 AuthorsCatherine A. Laughlin12
Estimated H-index: 12
(NIH: National Institutes of Health)
Background As increasing numbers of dengue vaccines and therapeutics are in clinical development, standardized consensus clinical endpoint definitions are urgently needed to assess the efficacy of different interventions with respect to disease severity. We aimed to convene dengue experts representing various sectors and dengue endemic areas to review the literature and propose clinical endpoint definitions for moderate and severe disease based on the framework provided by the WHO 2009 classific...
Published on Dec 1, 2018in BMC Genomics3.50
Uwe Groß24
Estimated H-index: 24
(GAU: University of Göttingen),
Elzbieta Brzuszkiewicz19
Estimated H-index: 19
(GAU: University of Göttingen)
+ 12 AuthorsCynthia Maria Chibani4
Estimated H-index: 4
(GAU: University of Göttingen)
Background Clostridioides difficile infections (CDI) have emerged over the past decade causing symptoms that range from mild, antibiotic-associated diarrhea (AAD) to life-threatening toxic megacolon. In this study, we describe a multiple and isochronal (mixed) CDI caused by the isolates DSM 27638, DSM 27639 and DSM 27640 that already initially showed different morphotypes on solid media.
Published on Aug 7, 2018in Frontiers in Microbiology4.26
Mwanaisha Seugendo2
Estimated H-index: 2
(Catholic University of Health and Allied Sciences),
Iryna Janssen2
Estimated H-index: 2
(GAU: University of Göttingen)
+ 15 AuthorsStephen E. Mshana21
Estimated H-index: 21
(Catholic University of Health and Allied Sciences)
Clostridioides (Clostridium) difficile infections (CDI) are considered worldwide as emerging health threat. Uptake of C. difficile spores may result in asymptomatic carrier status or lead to CDI that could range from mild diarrhea, eventually developing into pseudomembranous colitis up to a toxic megacolon that often results in high mortality. Most epidemiological studies to date have been performed in middle- and high income countries. Beside others, the use of antibiotics and the composition o...
E. R. Witjas-Paalberends1
Estimated H-index: 1
L. P. M. van Laarhoven1
Estimated H-index: 1
(VU: VU University Amsterdam)
+ 4 AuthorsW. T. M. Jansen1
Estimated H-index: 1
ABSTRACTBig data-driven innovations are key in improving healthcare system sustainability. Given the complexity, these are frequently conducted by public-private-partnerships (PPPs) between profit and non-profit parties. However, information on how to manage big data-driven healthcare innovations by PPPs is limited. This study elucidates challenges and best practices in managing big data-driven healthcare innovations by PPPs in the Netherlands. Fifteen technical, organizational, competence and e...
Published on May 4, 2018in PLOS Neglected Tropical Diseases4.49
Anne M. G. Neevel1
Estimated H-index: 1
(VU: VU University Amsterdam),
Tessa Hemrika1
Estimated H-index: 1
(VU: VU University Amsterdam)
+ 1 AuthorsLinda H. M. van de Burgwal2
Estimated H-index: 2
Background Despite the existence of safe and effective vaccines, rabies disease still causes an estimated 59,000 human deaths a year in the endemic areas in Asia and Africa. These numbers reflect severe drawbacks regarding the implementation of PrEP and PEP in endemic settings, such as lack of political will and low priority given to rabies. Since these contextual factors have proven to be persistent, there is an urgency to improve current strategies or develop novel approaches in order to contr...
Published on May 1, 2018in Preventive Veterinary Medicine2.30
Verity Horigan4
Estimated H-index: 4
(Animal and Plant Health Agency),
M. De Nardi1
Estimated H-index: 1
+ 9 AuthorsM. Schuppers1
Estimated H-index: 1
Abstract We present a novel approach of using the multi-criteria pathogen prioritisation methodology as a basis for selecting the most appropriate case studies for a generic risk assessment framework. The approach uses selective criteria to rank exotic animal health pathogens according to the likelihood of introduction and the impact of an outbreak if it occurred in the European Union (EU). Pathogens were evaluated based on their impact on production at the EU level and international trade. A su...
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