Characterization of a semi-replicative gene delivery system allowing propagation of complementary defective retroviral vectors

Background Recently, several cancer gene therapy studies have shown that replication‐competent retroviral vectors represent a major improvement over replication‐defective ones in terms of transgene propagation efficiency. However, this positive effect is somewhat spoiled by the increased risk of dissemination and oncogenesis that replication‐competent retroviral vectors entail. To enhance both their integral safety and their transgene capacity,...