Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation

Unfixed and fixed postmortem multiple sclerosis (MS) brain is being used to probe pathology underlying quantitative MR (qMR) changes. Effects of fixation on qMR indices in MS brain are unknown. In 15 postmortem MS brain slices T 1 , T 2 , MT ratio (MTR), macromolecular proton fraction (f B ), fractional anisotropy (FA), and mean, axial, and radial diffusivity (MD, D ax , and D rad ) were assessed in white matter (WM) lesions (WML) and normal...