Drug–excipient compatibility screening—Role of thermoanalytical and spectroscopic techniques

Estimation of drug-excipient interactions is a crucial step in preformulation studies of drug development to achieve consistent stability, bioavailability and manufacturability of solid dosage forms. The advent of thermoanalytical and spectroscopic methods like DSC, isothermal microcalorimetry, HSM, SEM, FT-IR, solid state NMR and PXRD into pre-formulation studies have contributed significantly to early prediction, monitoring and...