Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines
Abstract
p21-activated protein kinase (PAK) serine/threonine kinases are important effectors of Rho family GTPases and have been implicated in the regulation of cell morphology and motility, as well as in cell transformation. To further investigate the possible involvement of PAK kinases in tumorigenesis, we analyzed the expression of several family members in tumor cell lines. Here we demonstrate that PAK4 is frequently overexpressed in human tumor cell...
Paper Details
Title
Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines
Published Date
Jan 1, 2002
Volume
277
Issue
1
Pages
550 - 558
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