Evidence for direct action of alloxan to induce insulin resistance at the cellular level
Abstract
To determine whether long-term insulin deficiency alters insulin movement across the endothelium, plasma and lymph dynamics were assessed in dogs after alloxan (50 mg/kg; n = 8) or saline injection (n = 6). Glucose tolerance (KG) and acute insulin response were assessed by glucose injection before and 18 days after treatment. Two days later, hyperglycaemic (16.7 mmol/l) hyperinsulinaemic (60 pmol x min(-1) x kg(-1)) glucose clamps were carried...
Paper Details
Title
Evidence for direct action of alloxan to induce insulin resistance at the cellular level
Published Date
Oct 20, 1998
Journal
Volume
41
Issue
11
Pages
1327 - 1336
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