Original paper
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
Abstract
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding autophagy-related 7). Unexpectedly, these mice showed decreased fat mass and were protected from diet-induced obesity and insulin resistance; this phenotype was accompanied by increased fatty acid oxidation and browning of white adipose tissue (WAT)...
Paper Details
Title
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
Published Date
Dec 2, 2012
Journal
Volume
19
Issue
1
Pages
83 - 92
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Notes
History