Interações entre síndrome da apnéia obstrutiva do sono e resistência à insulina

Published on Oct 1, 2007in Arquivos Brasileiros De Endocrinologia E Metabologia
· DOI :10.1590/S0004-27302007000700003
Glaucia Carneiro10
Estimated H-index: 10
(Federal University of São Paulo),
Fernando Flexa Ribeiro Filho8
Estimated H-index: 8
(Federal University of São Paulo)
+ 2 AuthorsMaria Teresa Zanella20
Estimated H-index: 20
(Federal University of São Paulo)
Previous studies have shown Obstructive Sleep Apnea (OSA) as a risk factor for development of cardiovascular and cerebrovascular disease. However, controversies remain as to whether these changes are consequences of the associated obesity or OSA itself results in endocrine and metabolic changes, including impairment of insulin sensitivity, growth hormone, secretion inflammatory cytokines alterations, activation of peripheral sympathetic activity, and hipothalamic-pituitary-adrenal (HPA) axis, that may predispose to vascular disease. Furthermore many cardiovascular risk factors, such as hypertension, obesity, insulin resistance and type 2 diabetes, are strongly associated with OSA. In this article, we will review the evidence and discuss possible mechanisms underlying these links and the pathophysiology of OSA morbidities.
  • References (43)
  • Citations (11)
Published on Sep 1, 1993in Sleep 5.13
Ian Wilcox23
Estimated H-index: 23
(Royal Prince Alfred Hospital),
Ronald R. Grunstein60
Estimated H-index: 60
(Royal Prince Alfred Hospital)
+ 5 AuthorsColin E. Sullivan18
Estimated H-index: 18
(Royal Prince Alfred Hospital)
184 Citations Source Cite
Published on Sep 1, 1993in International Journal of Obesity 5.16
R. Grunstein1
Estimated H-index: 1
I. Wilcox1
Estimated H-index: 1
+ 2 AuthorsJ. Hedner1
Estimated H-index: 1
The objective of this study was to examine the relationship between sleep apnoea, measures of obesity and blood pressure. The study was cross-sectional in design, involving 1464 consecutive men undergoing sleep studies at two non-hospital sleep laboratories. Detailed sleep studies, body mass index (BMI), neck, hip and waist circumferences and morning and evening blood pressures were measured in each patient. Twenty-eight per cent of patients were obese (BMI > 30 kg/m2) and 47% were overweight (B...
276 Citations
Published on Aug 1, 1998in Thorax 9.65
Erich W. Russi48
Estimated H-index: 48
(University of Zurich)
STUDY OBJECTIVES: Pulmonary barotrauma (PBT) of ascent is a feared complication in compressed air diving. Although certain respiratory conditions are thought to increase the risk of suffering PBT and thus should preclude diving, in most cases of PBT, risk factors are described as not being present. The purpose of our study was to evaluate factors that possibly cause PBT. DESIGN: We analyzed 15 consecutive cases of PBT with respect to dive factors, clinical and radiologic features, and lung funct...
63 Citations Source Cite
Published on Jul 1, 2003in Respiratory Physiology & Neurobiology 1.79
Naresh M. Punjabi49
Estimated H-index: 49
(Johns Hopkins University),
Murtuza M. Ahmed1
Estimated H-index: 1
(Johns Hopkins University)
+ 2 AuthorsChristopher P. O'Donnell37
Estimated H-index: 37
(Johns Hopkins University)
Abstract Sleep-disordered breathing (SDB) is a common condition with prevalence estimates of 2–4% in the general population. Epidemiological data suggest that SDB is an independent risk factor for cardiovascular disease. Glucose intolerance and insulin resistance are also well-recognized risk factors for the development of cardiovascular disease. A number of recent clinic-based studies suggest that, independent of obesity, SDB may adversely affect glucose tolerance and insulin sensitivity. The p...
231 Citations Source Cite
Published on Mar 1, 2000in Cytokine 3.51
Gunther Hartmann64
Estimated H-index: 64
(Ludwig Maximilian University of Munich),
Matthias H. Tschöp76
Estimated H-index: 76
(Ludwig Maximilian University of Munich)
+ 6 AuthorsMarcel Toepfer9
Estimated H-index: 9
Abstract Hypoxic pulmonary vasoconstriction is associated with but may not be sufficient for the development of high-altitude pulmonary oedema (HAPO). Hypoxia is known to induce an inflammatory response in immune cells and endothelial cells. It has been speculated that hypoxia-induced inflammatory cytokines at high altitude may contribute to the development of HAPO by causing capillary leakage in the lung. We were interested if such an inflammatory response, possibly involved in a later developm...
251 Citations Source Cite
Published on Jan 1, 2005in Obesity Research
Robert Wolk30
Estimated H-index: 30
(Mayo Clinic),
Anna Svatikova17
Estimated H-index: 17
(Mayo Clinic)
+ 4 AuthorsVirend K. Somers95
Estimated H-index: 95
(Mayo Clinic)
Objective: Obstructive sleep apnea (OSA) is associated with obesity, sympathetic activation, systemic inflammation, and cardiovascular morbidity. Obesity, β-adrenergic agonists, and inflammation are linked to decreased expression and/or secretion of an adipose tissue-derived antiatherogenic hormone, adiponectin. The purpose of the study was to investigate whether OSA affected plasma levels of adiponectin, which might help explain OSA-associated cardiovascular morbidity. Research Methods and Proc...
75 Citations Source Cite
Belinda Brooks13
Estimated H-index: 13
(Royal Prince Alfred Hospital),
Peter A. Cistulli3
Estimated H-index: 3
(Royal Prince Alfred Hospital)
+ 5 AuthorsDennis K. Yue46
Estimated H-index: 46
(Royal Prince Alfred Hospital)
Patients with noninsulin-dependent diabetes mellitus (NIDDM) are often obese and frequently complain of tiredness. These features are also characteristically seen in patients with obstructive sleep apnea (OSA). Therefore, it was the aim of this study to assess the prevalence of OSA among a group of obese NIDDM patients who have some clinical features of OSA. The effect of reversal of OSA by nasal continuous positive airway pressure (CPAP) treatment on insulin responsiveness was also investigated...
238 Citations Source Cite
Published on Mar 1, 1991in Biological Psychiatry 11.98
E. Späth-Schwalbe2
Estimated H-index: 2
M. Gofferje1
Estimated H-index: 1
+ 2 AuthorsHorst L. Fehm43
Estimated H-index: 43
Recent studies have provided evidence that nocturnal cortisol secretion is coupled to ultradian rhythms of sleep. The present study was designed to specify how exogenous and sleep-related endogenous factors influence nocturnal adrenocorticotropin (ACTH) and cortisol secretion. We compared the influences of (1) temporary sleep deprivation, (2) arousals continuously induced during sleep and , (3) undisturbed sleep (baseline) on pituitary-adrenocortical activity in 10 healthy men. Sleep deprivation...
185 Citations Source Cite
Published on May 1, 2001in International Journal of Obesity 5.16
Onofrio Resta32
Estimated H-index: 32
Maria P. Foschino-Barbaro26
Estimated H-index: 26
+ 6 AuthorsG. De Pergola24
Estimated H-index: 24
Sleep-related breathing disorders, loud snoring and excessive daytime sleepiness in obese subjects
240 Citations Source Cite
Published on Mar 25, 2005in The Lancet 53.25
José María Marín-Trigo39
Estimated H-index: 39
Santiago Carrizo15
Estimated H-index: 15
+ 1 AuthorsAlvar Agusti85
Estimated H-index: 85
Summary Background The effect of obstructive sleep apnoea-hypopnoea as a cardiovascular risk factor and the potential protective effect of its treatment with continuous positive airway pressure (CPAP) is unclear. We did an observational study to compare incidence of fatal and non-fatal cardiovascular events in simple snorers, patients with untreated obstructive sleep apnoea-hypopnoea, patients treated with CPAP, and healthy men recruited from the general population. Methods We recruited men with...
3,000 Citations Source Cite
  • References (43)
  • Citations (11)
Cited By11
Published on Jan 1, 2009in Biotemas
Humberto Gabriel Rodrigues3
Estimated H-index: 3
(Federal University of Uberlandia),
Maria Thereza Alves Batista1
Estimated H-index: 1
(Federal University of Uberlandia)
+ 1 AuthorsTales Alexandre Aversi-Ferreira9
Estimated H-index: 9
(Universidade Federal de Goiás)
Apesar da sua aplicacao em outros setores, a agricultura tem sido a maior fonte de contaminacao ambiental por praguicidas. Alguns praguicidas e seus metabolitos tem sido encontrados como poluentes no fundo e superficie de aguas, no solo, e na atmosfera e sao provaveis responsaveis pela perda da biodiversidade e a deterioracao de habitats naturais. Dentre os herbicidas, o Roundup® (Brasil) e o mais comum. Estudos recentes tem demonstrado que o glifosato, o pesticida mais utilizado na agricultura ...
3 Citations Source Cite
Paula Caitano Fontela3
Estimated H-index: 3
Eliane Roseli Winkelmann4
Estimated H-index: 4
+ 1 AuthorsEvelise Moraes Berlezi6
Estimated H-index: 6
Introduction Sleep respiratory disorders (SRDs) are often found in patients with type 2 diabetes mellitus (T2DM). Objective The aim was to establish the prevalence of risk to develop an SRD using the Clinical Berlin Questionnaire (CBQ) and Epworth Sleepiness Scale (ESS) in patients with T2DM and verifying the correlation of anthropometric measurements and life quality (LQ) with ESS. Methods A descriptive and analytical study of a case series evaluating 208 patients with T2DM, submitted to clinic...
Source Cite
Published on Mar 1, 2014in Endocrine Practice 3.81
L. Tock6
Estimated H-index: 6
Glaucia Carneiro10
Estimated H-index: 10
+ 4 AuthorsMaria Teresa Zanella20
Estimated H-index: 20
Objective: Some studies have shown a higher prevalence of nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea (OSA) in patients with polycystic ovary syndrome (PCOS). The objective of this study was to assess NAFLD in PCOS women with and without OSA. A possible role of high serum androgen levels in the development of OSA in PCOS women was also investigated.Methods: Biochemical, hormonal, and polysomnography parameters were determined in 38 premenopausal PCOS patients. NAFLD was ...
10 Citations Source Cite
Published on Dec 1, 2011in Otolaryngology-Head and Neck Surgery 2.44
Yuan Ping Xiong2
Estimated H-index: 2
Hongliang Yi12
Estimated H-index: 12
+ 6 AuthorsBin Chen5
Estimated H-index: 5
Objectives. To investigate predictors of surgical outcomes of uvulopalatopharyngoplasty (UPPP) for obstructive sleep apnea hypopnea syndrome (OSAHS).Study Design. Case series with planned data collection.Setting. A university medical center.Subjects and Methods. Thirty-nine patients with OSAHS received Z-palatopharyngoplasty (ZPPP) or Han-uvulopalatopharyngoplasty (H-UPPP). All patients were evaluated within 3 months before surgery and at 6 to 12 months after surgery. Statistical analyses were c...
14 Citations Source Cite
Objetivo Investigar a inter-relacao entre proteina C-reativa de alta sensibilidade e hemoglobina glicada na predicao do risco de apneia obstrutiva do sono. Metodos Foram incluidos todos os individuos participantes do programa de check-up do Centro de Medicina Preventiva Hospital Israelita Albert Einstein em 2014. Foi aplicado o questionario de Berlin sobre risco de apneia do sono, e avaliadas as dosagens de hemoglobina glicada e proteina C-reativa de alta sensibilidade. Resultados Foram incluido...
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