Antiobesity actions of Embelia ribes

Embelia ribes has been used as a folk medicine whole world. An aqueous extract of Embelia ribes have visceral fat accumulation and improved insulin resistance in rat model with HFD induced obesity may possibly be through down regulation of leptin, TNF-α, SREBP1γ, and PPARγ2 gene expression. The leptin might contribute to hepatic steatosis by promoting insulin resistance and also by altering insulin signaling in hepatocytes, which consequently...