Adipocyte morphology and implications for metabolic derangements in acquired obesity

Adipocyte size and number have been suggested to predict the development of metabolic complications in obesity. However, the genetic and environmental determinants behind this phenomenon remain unclear. We studied this question in rare-weight discordant (intra-pair difference (Δ) body mass index (BMI) 3–10 kg m−2, n=15) and concordant (ΔBMI 0–2 kg m−2, n=5) young adult (22–35 years) monozygotic twin pairs identified from 10 birth cohorts of...