Crystal Structure of Human Enterovirus 71
Abstract
Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the...
Paper Details
Title
Crystal Structure of Human Enterovirus 71
Published Date
Jun 8, 2012
Journal
Volume
336
Issue
6086
Pages
1274 - 1274
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