Mineralocorticoid Receptor Antagonists and the Metabolic Syndrome
Abstract
Key components of the metabolic syndrome (MetS), ie, obesity and insulin resistance, are associated with increased aldosterone production and mineralocorticoid receptor (MR) activation. Both MetS and hyperaldosteronism are proinflammatory and pro-oxidative states associated with cardiovascular disease. This review discusses emerging data that MR activation may contribute to abnormalities seen in MetS. In view of these data, MR antagonists may be...
Paper Details
Title
Mineralocorticoid Receptor Antagonists and the Metabolic Syndrome
Published Date
Jun 19, 2010
Journal
Volume
12
Issue
4
Pages
252 - 257
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