Discovering potent and selective reversible inhibitors of enzymes in complex proteomes
Abstract
To realize the promise of genomics-based therapeutics, new methods are needed to accelerate the discovery of small molecules that selectively modulate protein activity. Toward this end, advances in combinatorial synthesis have provided unprecedented access to large compound libraries of considerable structural complexity and diversity, shifting the bottleneck in drug discovery to the development of efficient screens for protein targets....
Paper Details
Title
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes
Published Date
May 12, 2003
Journal
Volume
21
Issue
6
Pages
687 - 691
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Notes
History