A survey on quantitative microdialysis: theoretical models and practical implications

The existing methods of quantitative microdialysis are reviewed. The methods are divided into 8 groups, depending on the mathematical models and theoretical principles used to describe convective diffusion in the extracellular space of the brain. Special emphasis is made to describe each method from a historical perspective, showing its main contribution to recent knowledge, as well as its limitations and drawbacks. It is concluded that those...