RING Finger Proteins

Until recently no specific function had been ascribed to the RING finger beyond a role in dimerization of several proteins. Over the last year and a half, however, reports from a number of laboratories studying diverse biological processes have led to the realization that RING finger proteins play critical roles in mediating the transfer of ubiquitin (Ub) both to heterologous substrates as well as to the RING finger proteins themselves. As RING...