PC12 variants deficient in norepinephrine transporter mRNA have wild type activities of several other related transporters

Wild type PC12 pheochromocytoma cells express a Na+-dependent norepinephrine transporter that operates in the uptake of catecholamines. In addition to the previously described Na+-dependent system A for the uptake of α-amino-isobutyric acid and system Gly for glycine, we have identified two other Na+-dependent transporter systems for amino acid uptake in these cells: 1) system β for β-alanine and taurine; and 2) a system for creatine. Uptake of...