SWI/SNF nucleosome remodellers and cancer
Abstract
SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel nucleosomes and to modulate transcription. Growing evidence indicates that these complexes have a widespread role in tumour suppression, as inactivating mutations in several SWI/SNF subunits have recently been identified at a high frequency in a variety of cancers. However, the mechanisms by which mutations in these complexes drive tumorigenesis are unclear. In...
Paper Details
Title
SWI/SNF nucleosome remodellers and cancer
Published Date
Jun 9, 2011
Journal
Volume
11
Issue
7
Pages
481 - 492
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