A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation
Abstract
The molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the B cell antigen receptor (pre-BCR) in B lymphopoiesis has not been elucidated. Here we demonstrate that in pre-B cells, the IL-7R but not the pre-BCR was coupled to phosphatidylinositol-3-OH kinase (PI(3)K) and the kinase Akt; signaling by this pathway inhibited expression of recombination-activating gene 1 (Rag1) and Rag2. Attenuation of IL-7 signaling...
Paper Details
Title
A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation
Published Date
Jan 22, 2012
Journal
Volume
13
Issue
3
Pages
300 - 307
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