Efficacy and Effectiveness of Antidepressants: Current Status of Research

This paper examines the current status of research on the efficacy and effectiveness of antidepressants.This paper reviews four meta-analyses of efficacy trials submitted to America's Food and Drug Administration (FDA) and analyzes STAR*D (Sequenced Treatment Alternatives to Relieve Depression), the largest antidepressant effectiveness trial ever conducted.Meta-analyses of FDA trials suggest that antidepressants are only marginally efficacious...