Novel irinotecan-loaded liposome using phytic acid with high therapeutic efficacy for colon tumors
Abstract
Phytic acid (IP-6) is a polyphosphorylated carbohydrate with antitumor activity for many kinds of tumors. In this study, we developed a novel method of loading irinotecan (CPT-11) into liposomes using IP-6, and evaluated its antitumor effect on colon tumors in vivo. Liposomal CPT-11 was prepared by loading CPT-11 to distearoylphosphatidylcholine/cholesterol/methoxy-poly(ethyleneglycol)-distearylphosphatidylethanolamine liposomes prepared in IP-6...
Paper Details
Title
Novel irinotecan-loaded liposome using phytic acid with high therapeutic efficacy for colon tumors
Published Date
May 1, 2009
Volume
136
Issue
1
Pages
30 - 37
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