Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry

Volume: 110, Issue: 10, Pages: 3865 - 3870
Published: Mar 5, 2013
Abstract
Double-stranded DNA (dsDNA) unconstrained by torsion undergoes an overstretching transition at about 65 pN, elongating the DNA to about 1.7-fold. Three possible structural transitions have been debated for the nature of DNA overstretching: (i) “peeling” apart of dsDNA to produce a peeled ssDNA strand under tension while the other strand coils, (ii) “inside-strand separation” of dsDNA to two parallel ssDNA strands that share tension (melting...
Paper Details
Title
Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry
Published Date
Mar 5, 2013
Volume
110
Issue
10
Pages
3865 - 3870
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