High-content single-cell drug screening with phosphospecific flow cytometry
Abstract
Drug screening is often limited to cell-free assays involving purified enzymes, but it is arguably best applied against systems that represent disease states or complex physiological cellular networks. Here, we describe a high-content, cell-based drug discovery platform based on phosphospecific flow cytometry, or phosphoflow, that enabled screening for inhibitors against multiple endogenous kinase signaling pathways in heterogeneous primary cell...
Paper Details
Title
High-content single-cell drug screening with phosphospecific flow cytometry
Published Date
Dec 23, 2007
Journal
Volume
4
Issue
2
Pages
132 - 142
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