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Suppression of Lymphocyte Mitogenesis by Tamoxifen: Studies on Protein Kinase C, Calmodulin and Calcium

Published on Jan 1, 2000in Neuroimmunomodulation1.35
· DOI :10.1159/000026422
Edward Baral13
Estimated H-index: 13
,
Eva Nagy22
Estimated H-index: 22
+ 3 AuthorsIstvan Berczi32
Estimated H-index: 32
Cite
Abstract
The effect of tamoxifen (TX; 1.0 μ M ) on the mitogenic response of rat lymphocytes was compared with the effect of drugs that are known to act on protein kinase C (PKC), calmodulin (
  • References (35)
  • Citations (9)
Cite
References35
Newest
Published on Aug 19, 1996in FEBS Letters2.67
Sietse Mosselman19
Estimated H-index: 19
(Organon International),
Jan Polman7
Estimated H-index: 7
(Organon International),
Rein Dijkema9
Estimated H-index: 9
(Organon International)
A novel estrogen receptor (hereinafter referred to as ERβ) was cloned using degenerate PCR primers. A comparison of the amino acid sequence of ERβ with the ‘classical’ ER (ERα) shows a high degree of conservation of the DNA-binding domain (96%), and of the ligand-binding domain (58%). In contrast, the A/B domain, the hinge region and the F-domain are not conserved. Northern blot analysis revealed that ERβ is expressed in human thymus, spleen, ovary and testis. Transient transfections of an ERβ e...
Published on Jan 1, 1996
Edward Baral13
Estimated H-index: 13
,
Eva Nagy22
Estimated H-index: 22
,
Istvan Berczi32
Estimated H-index: 32
The nonsteroidal anti-estrogenic agent, Tamoxifen (TX)*, is widely applied for the treatment of breast carcinomas and of some other sex hormone dependent tumors (Patterson and Battersby, 1980). It is generally accepted that the mechanism of action of TX on these tumors is due to its antiestrogenic properties, which is exerted through its binding to of the estrogen receptor but without the growth promoting effect of estradiol (E2). For this reason, TX and related drugs (toremifene-TO, ethamoxytri...
Published on Jan 15, 1995in Cancer6.10
Edward Baral13
Estimated H-index: 13
(UM: University of Manitoba),
Eva Nagy22
Estimated H-index: 22
(UM: University of Manitoba),
Istvan Berczi32
Estimated H-index: 32
(UM: University of Manitoba)
Background. The nonsteroidal antiestrogenic drug, tamoxifen, inhibits the growth of estrogen receptor-positive tumors by interfering with the growth-stimulatory effect of estradiol. However, there is compelling evidence that tamoxifen treatment also is beneficial for patients with estrogen receptor-negative tumors. The hypothesis that tamoxifen is capable of enhancing the immunologic defense of tumor-bearing hosts was been investigated as a possible method for targeting receptor-negative neoplas...
Published on Jul 1, 1994in International Journal of Cancer4.98
Edward Baral13
Estimated H-index: 13
(UM: University of Manitoba),
Eva Nagy And1
Estimated H-index: 1
(UM: University of Manitoba),
Istvan Berczi32
Estimated H-index: 32
(UM: University of Manitoba)
The effect of estradiol (E2) and tamoxifen (TX) on cytotoxic T-tymphocyte (CTL)-mediated target-cell lysis was studied. CTL was generated in mixed cultures of rat spleen cells, using female Fischer 344 rat cells as responders and female Wistar rat cells or Nb2 rat lymphoma cells as stimulators. Concanavalin-A-stimulated Wistar lymphoblasts or Nb2 cells were used as targets. CTL harvested on day 5 exerted 16-25% cytotoxicity when used at 1:12-1:50 target:effector cell ratios. Day-6 CTL had no cyt...
Published on Apr 1, 1994in European Journal of Immunology4.70
Fred Ramsdell24
Estimated H-index: 24
,
Michael S. Seaman67
Estimated H-index: 67
+ 3 AuthorsDavid H. Lynch47
Estimated H-index: 47
Mice homozygous for either the lpr or gld genes develop phenotypically identical autoimmune disorders. The gene responsible for the pathology in lpr/lpr mice encodes the Fas antigen, a protein associated with the induction of programmed cell death. To determine if the defect associated with gld represents a mutation in the ligand for Fas, we have assessed the ability of lymphoid cells from homozygous gld/gld mice to lyse target cells in a Fas-dependent manner. Using an antagonistic antibody to F...
Published on Mar 1, 1994in Cell36.22
Tomohiro Takahashi8
Estimated H-index: 8
(Osaka Bioscience Institute),
Masato Tanaka46
Estimated H-index: 46
(Osaka Bioscience Institute)
+ 4 AuthorsShigekazu Nagata S112
Estimated H-index: 112
(Osaka Bioscience Institute)
Abstract Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and suffer from autoimmune disease. The lpr mice have a mutation in a cell-surface protein, Fas, that mediates apoptosis. Fas ligand (FasL) is a tumor necrosis factor (TNF)-related type II membrane protein and binds to Fas. Here, mouse Fasl gene was isolated and localized to the gld region of mouse chromosome 1. Activated spienocytes from gld mice express Fasl mRNA. How...
Published on Jan 1, 1994in Neuroimmunomodulation1.35
Istvan Berczi32
Estimated H-index: 32
(UM: University of Manitoba)
The influence of various members of the growth and lactogenic hormone family on the immune system is reviewed. A general hypothesis is proposed for growth control in higher animals. It is suggested th
Published on Dec 1, 1993in Cell36.22
Takashi Suda41
Estimated H-index: 41
(Osaka Bioscience Institute),
Tomohiro Takahashi8
Estimated H-index: 8
(Osaka Bioscience Institute)
+ 1 AuthorsShigekazu Nagata S112
Estimated H-index: 112
(Osaka Bioscience Institute)
Abstract The Fas antigen (Fas) belongs to the tumor necrosis factor (TNF)/nerve growth factor receptor family, and it mediates apoptosis. Using a soluble form of mouse Fas, prepared by fusion with human immunoglobulin Fc, Fas ligand was detected on the cell surface of a cytotoxic T cell hybridoma, PC60-d10S. A cell population that highly expresses Fas ligand was sorted using a fluorescence-activated cell sorter, and its cDNA was isolated from the sorted cells by expression cloning. The amino aci...
Published on Aug 1, 1993in Journal of Experimental Medicine10.89
Manuel López-Cabrera41
Estimated H-index: 41
,
Ana G. Santis7
Estimated H-index: 7
+ 4 AuthorsFrancisco Sánchez-Madrid88
Estimated H-index: 88
The activation of T lymphocytes, both in vivo and in vitro, induces the expression of CD69. This molecule, which appears to be the earliest inducible cell surface glycoprotein acquired during lymphoid activation, is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. To determine the structural basis for CD69 function, the cDNA coding for CD69 was isolated by a polymerase chain reaction-based strategy usin...
Cited By9
Newest
Published on Sep 20, 2019in Pharmaceuticals
Lamin B. Cham1
Estimated H-index: 1
,
Sarah-Kim Friedrich2
Estimated H-index: 2
+ 11 AuthorsMurtaza Ali
Background: Tamoxifen (TAM) is an estrogen-receptor antagonist, widely used in the adjuvant treatment of early stage estrogen-sensitive breast cancer. Several studies have revealed new biological targets of TAM that mediate the estrogen receptor independent activities of the drug. Recently, the antiviral activity of TAM on replication of human immunodeficiency virus (HIV), hepatitis C virus (HCV) and Herpes simplex virus (HSV-1) in vitro was described. In the current study, we aimed to investiga...
Published on Jan 1, 2014in Advances in neuroimmune biology
Istvan Berczi32
Estimated H-index: 32
,
Andres Quintanar Stephano1
Estimated H-index: 1
+ 1 AuthorsKalman Kovacs68
Estimated H-index: 68
Growth hormone and prolactin maintain adaptive immunity, which incudes cell mediated immunity, antibody- and autoimmune reactions, maintain thymus and bone marrow function. Insulin like growth factor-1 participate in the regulatory action of growth hormone and prolactin. The hypothalamus-pituitary-adrenal axis stimulates innate immunity and suppresses adaptive immunity. Dopamine also inhibits adaptive immunity and regulates innate immunity. Catecholamine's and corticosteroids support innate immu...
Published on Mar 1, 2009in Vaccine3.27
Carla De Giovanni33
Estimated H-index: 33
(UNIBO: University of Bologna),
Giordano Nicoletti38
Estimated H-index: 38
+ 11 AuthorsValeria Stivani5
Estimated H-index: 5
(UNIBO: University of Bologna)
The possible interference of tamoxifen with anti-tumor vaccines was studied in a translational view of combined preventive approaches. Tamoxifen treatment of HER-2/neu transgenic mice combined to anti-HER-2/neu cell vaccine did not hamper the efficacy of cancer immunoprevention, and caused a significantly increased production of interferon-γ. These data suggest that tamoxifen could even have a positive impact on the efficacy of cancer immunoprevention.
Published on Jul 1, 2007in Hippocampus3.27
Jing Xu5
Estimated H-index: 5
(Xuzhou Medical College),
Quanguang Zhang17
Estimated H-index: 17
(Xuzhou Medical College)
+ 1 AuthorsGuang Yi Zhang14
Estimated H-index: 14
(Xuzhou Medical College)
Previous studies have shown that subtoxic NMDA moderated the neuronal survival in vitro and vivo. We performed this experiment to clarify the precise mechanism underlie subtoxic NMDA delayed neuronal death in ischemic brain injury. We found that pretreatment of NMDA (100 mg/kg) increased the number of the surviving CA1 pyramidal cells of hippocampus at 5 days of reperfusion. This dose of NMDA could also enhance Akt activation after ischemia/reperfusion (I/R). Here, we examined the possible mecha...
Published on Oct 1, 2006in Clinical Cancer Research8.91
Edward M. Curran16
Estimated H-index: 16
,
Barbara M. Judy13
Estimated H-index: 13
+ 4 AuthorsD. Mark Estes31
Estimated H-index: 31
Purpose: The risk of developing breast cancer is positively correlated with exposure to increased levels of estrogen and/or an increased duration of estrogen exposure. Many different mechanisms have been proposed to explain the association of estrogens with breast cancer risk; however, the well-documented immune modulatory properties of estrogen have received little attention. In part, this is due to a lack of suitable models for studying this relationship. Experimental Design: We have developed...
Published on Apr 1, 2005in Pediatric Research2.88
Ming Li23
Estimated H-index: 23
,
Min Zhang7
Estimated H-index: 7
+ 5 AuthorsRichard M Whitehurst6
Estimated H-index: 6
T-Type Ca 2+ Channels Are Involved in High Glucose–Induced Rat Neonatal Cardiomyocyte Proliferation
Published on Sep 1, 2004in The Journal of Clinical Pharmacology2.92
Mohamed A. Kamal1
Estimated H-index: 1
(UB: University at Buffalo),
William J. Jusko64
Estimated H-index: 64
(UB: University at Buffalo)
Systemic lupus erythematosus is an autoimmune disease primarily affecting women. Currently, systemic lupus erythematosus therapy is suboptimal due to adverse effects of immunosuppressants, particularly corticosteroids. This study determines the single effects of prednisolone, dehydroepiandrosterone, bromocriptine, tamoxifen, mycophenolic acid, 2-chloro-2′-deoxyadenosine, azathioprine, and chloroquine on lectin-stimulated proliferation of human T lymphocytes, as well as determining whether there ...
Published on Feb 1, 2003in Biochemical Pharmacology4.83
Andrzej Teisseyre6
Estimated H-index: 6
(Wrocław Medical University),
Krystyna Michalak22
Estimated H-index: 22
(Wrocław Medical University)
Abstract Phenothiazines are well-known calmodulin inhibitors that interact with many receptors and channels including a variety of potassium channels. In this study, we report a blocking effect of trifluoperazine (TFP) on voltage-gated Kv1.3 channels expressed in human T lymphocytes. Application of TFP in the concentration range from 1 to 20 μM reduced the current amplitude to about a half of the control value. The currents were blocked to less than 0.05 of the control value at 50 μM TFP concent...
Published on Jan 1, 2003in Clinical Cancer Research8.91
Erich Solomayer37
Estimated H-index: 37
(University of Tübingen),
Markus Feuerer22
Estimated H-index: 22
+ 6 AuthorsIngo J. Diel28
Estimated H-index: 28
Purpose: Bone marrow is a special compartment for antitumor immunological memory in patients with breastcancer. Until now, the influence of adjuvant systemic therapy on the immune system has only been investigated in peripheral blood and not in bone marrow. In this study, we analyzed the effect of hormone therapy and chemotherapy on the immune activation status in bone marrow. Experimental Design: In 34 patients with breast cancer, bone marrow was aspirated 24 months after primary surgery and ad...
Published on Jul 21, 2002in Toxicology Letters3.50
Humitoshi Sakazaki4
Estimated H-index: 4
(Setsunan University),
Hitoshi Ueno15
Estimated H-index: 15
(Setsunan University),
Katsuhiko Nakamuro19
Estimated H-index: 19
(Setsunan University)
Abstract To elucidate relevance of estrogens to immune responses, we investigated whether estrogen receptor α (ER α ) exists in mouse splenic B cells and T cells and the effect of 17β-estradiol and endocrine disrupting chemicals (EDCs) on lymphocyte mitogenesis. ER α was identified in both male and female mouse splenic cells using RT-PCR. Crude splenic cells were stained with anti-ER antibody, and the distribution of ER α in the splenic B cells and part of the splenic T cells was confirmed by fl...
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