Mast cell tryptase: a review of its physiology and clinical significance

Summary Mast cells, which are granulocytes found in peripheral tissue, play a central role in inflammatory and immediate allergic reactions. β‐Tryptase is a neutral serine protease and is the most abundant mediator stored in mast cell granules. The release of β‐tryptase from the secretory granules is a characteristic feature of mast cell degranulation. While its biological function has not been fully clarified, mast cell β‐tryptase has an...