Original paper
Amyloid β‐Mediated Oxidative and Metabolic Stress in Rat Cortical Neurons: No Direct Evidence for a Role for H2O2 Generation
Abstract
: H 2 O 2 and free radical‐mediated oxidative stresses have been implicated in mediating amyloid β(1–40) [Aβ(1–40)] neurotoxicity to cultured neurons. In this study, we confirm that addition of the H 2 O 2 ‐scavenging enzyme catalase protects neurons in culture against Aβ‐mediated toxicity; however, it does so by a mechanism that does not involve its ability to scavenge H 2 O 2 . Aβ‐mediated elevation in intracellular H 2 O 2 production is...
Paper Details
Title
Amyloid β‐Mediated Oxidative and Metabolic Stress in Rat Cortical Neurons: No Direct Evidence for a Role for H2O2 Generation
Published Date
Oct 1, 1996
Journal
Volume
67
Issue
4
Pages
1595 - 1606
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Notes
History