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A Comparative Study on the Effects of Excessive Consumption of Ginger, Clove, Red Pepper and Black Pepper on the Histology of the Kidney

Published on Feb 1, 2008in Pakistan Journal of Nutrition
· DOI :10.3923/pjn.2008.287.291
A.O. Nwaopara2
Estimated H-index: 2
(Ambrose Alli University),
M.A.C. Odike2
Estimated H-index: 2
(Ambrose Alli University)
+ 2 AuthorsG.I. Ewere1
Estimated H-index: 1
(Ambrose Alli University)
Cite
Abstract
Allergic reactions have been associated with cloves, black pepper and mast cells. The presence of mast cells and renal fibrosis has also been reported and in line with an ongoing investigation on the effects of excessive consumption of Yaji the complex Nigerian meat sauce, this study was designed to correlate the individual and combined effects of the excessive consumption of Yaji-spices (ginger, clove, red pepper and black pepper) on the histology of the kidney, using 12 adult rabbits. The animals were divided into six groups of two (2) each (A, B, C, D, E and F). Groups B, C, D, E and F were the test groups whereas group A is the control. For 21 days, test group B was fed with feed and a combination of all the yaji-spices (3g each) while test groups C, D, E, and F were fed with feed and 3g each of the spices per day respectively. The histological observations showed that there were no effect on the kidneys in test groups C and E whereas in B, D and F, there were distinct round basophilic bodies in the interstitium of the renal cortex, which were suspected to be mast cells, and hence, implicating cloves and black pepper. This result suggests a possible mechanism of renal damage that is clove and black pepper feeding-induced, duration dependent and with mast cell mobilization into the kidney, that may then trigger renal fibrosis.
  • References (19)
  • Citations (14)
Cite
References19
Newest
Published on Jan 1, 2006in Biofactors 3.60
Anurag Kuhad27
Estimated H-index: 27
(Panjab University, Chandigarh),
Naveen Tirkey15
Estimated H-index: 15
(Panjab University, Chandigarh)
+ 1 AuthorsKanwaljit Chopra42
Estimated H-index: 42
(Panjab University, Chandigarh)
Background: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Recent evidence suggests that enhanced oxidative stress caused by oxygen-centered free radicals may contribute to the pathogenesis of cisplatin-induced acute renal failure. 6-Gingerol is claimed to be a potent antioxidant. The present study was performed to explore the renoprotective potential of 6-gingerol on cisplatin-induced oxidative stress and renal dysfunction. Methods: 6-Gingerol in dosage...
Published on Jan 1, 2005in Chemical & Engineering News 0.69
Pamela Zurer10
Estimated H-index: 10
Published on May 1, 2003in Current Medicinal Chemistry 3.89
D. Kalemba1
Estimated H-index: 1
,
A. Kunicka1
Estimated H-index: 1
In recent years there has been an increasing interest in the use of natural substances, and some questions concerning the safety of synthetic compounds have encouraged more detailed studies of plant resources. Essential oils, odorous and volatile products of plant secondary metabolism, have a wide application in folk medicine, food flavouring and preservation as well as in fragrance industries. The antimicrobial properties of essential oils have been known for many centuries. In recent years (19...
Published on Jun 1, 2002in Journal of Ethnopharmacology 3.41
Alicia E. Consolini10
Estimated H-index: 10
(UNLP: National University of La Plata),
Marisol Gracı́a Sarubbio1
Estimated H-index: 1
(UNLP: National University of La Plata)
Abstract The effect of aqueous crude extract (ACE) of Eugenia uniflora L. (Myrtaceae) was studied on rat's perfused ventricles. This plant is used in South American traditional medicine as an antihypertensive and we already demonstrated previously its hypotensive properties. In this paper, maximal left intraventriclular pressure ( P ) of rat's hearts beating at 0.2 Hz firstly increased to 162.1±11.1% of basal value during 1–3 min of perfusing ACE 0.6%. Maximum rate of contraction (+ P ) also inc...
Published on Jul 1, 2001in Kidney International 8.31
Ahmed F. El-Koraie5
Estimated H-index: 5
(Alexandria University),
Nahed M. Baddour6
Estimated H-index: 6
(Alexandria University)
+ 2 AuthorsA. Meguid El Nahas1
Estimated H-index: 1
(Alexandria University)
Role of stem cell factor and mast cells in the progression of chronic glomerulonephritides. Background Mast cells (MCs) have been implicated in the pathogenesis of atherosclerosis and tissue fibrosis. However, the role of MC in the development of renal fibrosis has not been fully elucidated. Stem cell factor (SCF; the ligand for MC c-kit receptor) is thought to attract and activate MCs. Methods The intensity of MC infiltration and SCF expression in renal biopsies from 56 patients with different ...
Published on Jul 1, 2001in Kidney International 8.31
Allison A. Eddy22
Estimated H-index: 22
Histologically, progressive renal disease is characterized by an interstitial infiltrate of inflammatory cells in association with tubular atrophy and interstitial fibrosis. There are many reasons to believe that the mononuclear cells, especially those of monocytic lineage, play an active role in fibrogenesis even though definitive proof of their role is still lacking1. In this issue of Kidney International, El-Koraie et al investigate the presence of mast cells in the interstitium of human kidn...
Published on Jan 1, 2001in American Journal of Kidney Diseases 6.65
Allison A. Eddy30
Estimated H-index: 30
(UW: University of Washington)
Abstract Tubulointerstitial injury caused by multiple insults, including significant proteinuria, results in interstitial inflammation. Evidence supports the hypothesis that interstitial inflammatory cells initially recruited in response to injury subsequently contribute to interstitial fibrosis. Experimental manipulations that decrease the number of interstitial macrophages (Mφs) preserve renal function. Mφs have the potential to secrete a large number of products, including some with fibrosis-...
Published on Mar 1, 2000in Nephrology Dialysis Transplantation 4.20
Volker Nickeleit11
Estimated H-index: 11
,
Hans H. Hirsch60
Estimated H-index: 60
(University of Basel)
+ 4 AuthorsMichael J. Mihatsch71
Estimated H-index: 71
(University of Basel)
We review BK-virus nephropathy (BKN ) as Introduction a new complication that increasingly aVects renal allo- grafts and causes dysfunction. Since starting in 1996, Manifest polyomavirus infection of renal allografts we have seen 11 cases. Currently, the prevalence of with the BK-virus strain, i.e. BK-virus nephropathy BKN is 3% in our graft biopsies. The diagnosis can (BKN ), is an unusual complication that has recently only be made histologically. The virus aVects tubular been described (1-3)....
Published on Aug 1, 1999in Journal of Food Protection 1.56
Marlene E. Janes15
Estimated H-index: 15
,
Ramakrishna Nannapaneni15
Estimated H-index: 15
,
Michael G. Johnson30
Estimated H-index: 30
Two bacteriocin-producing bacterial strains were isolated from garlic and ginger root by the agar overlay method. The bacteria were identified by 16S rRNA sequence analyses and fermentation patterns as Leuconostoc mesenteroides (garlic isolate) and Lactococcus lactis (ginger isolate). The bacteriocins were assigned the names leucocin BC2 and lactocin GI3, respectively. Physiochemical properties and antimicrobial spectra of the bacteriocins were determined by the spot-on-lawn method. Both bacteri...
Published on Aug 1, 1999in Human Pathology 2.74
Cinthia B. Drachenberg54
Estimated H-index: 54
(UMB: University of Maryland, Baltimore),
Christian O. Beskow2
Estimated H-index: 2
(UMB: University of Maryland, Baltimore)
+ 7 AuthorsJohn C. Papadimitriou47
Estimated H-index: 47
(UMB: University of Maryland, Baltimore)
Human polyoma virus (PV) interstitial nephritis occurs in immunosuppressed patients after reactivation of latent virus in renal epithelium. Currently, there is neither general consensus about the incidence of clinically significant PV infection in renal transplants nor conclusive evidence determining its significance in the long-term graft outcome. We evaluated 601 renal transplant biopsy specimens (from 365 patients) by routine light microscopy and immunoperoxidase stains with antibody against ...
Cited By14
Newest
Published on Jun 1, 2016in Future Dental Journal
Ahmed Mahmoud Halawa1
Estimated H-index: 1
(Ain Shams University),
Dahlia Ghazy Mohamed1
Estimated H-index: 1
(Ain Shams University),
Raneem Farouk Obeid1
Estimated H-index: 1
(Future University in Egypt)
Abstract Capsaicin is a pungent principle of hot red pepper. It is used in spices, food additives and drugs. In the present work, twenty rats were divided into two groups: control and capsaicin groups, each consisting of ten rats. The capsaicin group daily received a capsaicin dose equivalent to 0.1 mg/kg body weight dissolved in 0.5 ml distilled water by oro-oesophageal tube while the control group daily received 0.5 ml distilled water. After twenty one days, the submandibular salivary glands o...
Published on May 1, 2016in Food and Chemical Toxicology 3.77
Nazmiye Ataseven1
Estimated H-index: 1
(Gazi University),
Deniz Yüzbaşıoğlu14
Estimated H-index: 14
(Gazi University)
+ 1 AuthorsFatma Ünal14
Estimated H-index: 14
(Gazi University)
Monosodium glutamate (MSG) is one of the most widely used flavor enhancers throughout the world. The aim of this study is to investigate the genotoxic potential of MSG by using chromosome aberrations (CAs), sister-chromatid exchanges (SCEs), cytokinesis-blocked micronucleus (CBMN), and random amplified polymorphic DNA-polimerase chain reaction (RAPD-PCR) in cultured human lymphocytes and alkaline comet assays in isolated human lymphocytes, which were incubated with six concentrations (250, 500, ...
Published on Jul 3, 2015
Journal of Pharmaceutical and Biological Sciences (An international peer-reviewed Bi-monthly journal) is a peer-reviewed journal of high quality devoted to provide a platform to scientists and researchers all over the world, for the dissemination of knowledge in the field of Pharmaceutical, Biological and other allied sciences. The journal policy is to publish work deemed by peer reviewers to be a coherent and sound addition to scientific knowledge and to put less emphasis on interest levels, pr...
Published on Jan 1, 2014in Journal of Cytology and Histology
Zeinab A. Hassan2
Estimated H-index: 2
,
Manar Hamed Arafa5
Estimated H-index: 5
+ 2 AuthorsHanan Fathy Al-Saeed1
Estimated H-index: 1
Monosodium glutamate (MSG), a flavor enhancer, is used in modern nutrition to improve food palatability. The objectives of the current study were to investigate the effect of MSG on thymus as well as spleen structures and functions. Also, to evaluate the possibility of recovery after cessation of administration. Adult male rats were divided into three groups: control, MSG (3 g MSG/kg body weight daily for 8 weeks by oral gavages), and Recovery (MSG for same period and then left untreated for add...
Published on Jan 1, 2014
Mayank Agrawal1
Estimated H-index: 1
,
Sonam Agrawal1
Estimated H-index: 1
+ 4 AuthorsUttar Pradesh
Today, herbal medicine is becoming more and more popular as a safe and effective means of treatment for many different medical conditions. Herbs are often preferred because they are natural and do not put harmful chemicals into the body. Herbs are available fresh, as capsules, powders, extracts, roots, etc. Some people prefer to grow their own. Always seek advice from an expert before taking herbs as a supplement or as a health remedy. Traditional healers have long used botanicals to prevent or ...
Published on Jan 1, 2014
Sonam Agrawal1
Estimated H-index: 1
,
Varun Singh + 3 AuthorsMayank Agrawal1
Estimated H-index: 1
Today, herbal medicine is becoming more and more popular as a safe and effective means of treatment for many different medical conditions. Herbs are often preferred because they are natural and do not put harmful chemicals into the body. Herbs are available fresh, as capsules, powders, extracts, roots, etc.
Ukoha Ukoha Ukoha5
Estimated H-index: 5
,
Ogugua Augustine Egwu3
Estimated H-index: 3
+ 5 AuthorsUzozie Ofoego1
Estimated H-index: 1
The aim of this histological study is to determine the effect of yaji (a Nigerian meat sauce that is indiscriminately consumed) on the anterior pituitary gland based on the fact that there is evidence that some of its constituents have excitotoxic and neurotoxic potentials. Eighteen weeks old white albino rats of an average weight of 225g were used for this study. The animals were acclimatized for two weeks and the test substance was administered for eight weeks and weighed on weekly basis. Twen...
Published on Dec 1, 2012
Hala M. Ebaid3
Estimated H-index: 3
,
Hend M. Tag4
Estimated H-index: 4
Histological effects of Monosodium glutamate (MSG) commonly used as food additive on the spleen of adult Wistar rats were carefully studied. The rats (n=30), average weight of 115 gm were randomly assigned into four treatments (n=6) and control (n=6) groups. The rats in the treatment groups received 4 mg/kg IP of MSG for fourteen days, while the control group receives the same volume of distilled water intraperitoneally. The rats were sacrificed after the last day of injection (group 1) and on 1...
Published on Jan 1, 2012
This study was intended to determine the effect of salt, groundnut, monosodium glutamate and spices, especially in combinations as used in Yaji , on the histology of the brain. The rats were divided into nine (9) groups (A – I) of eight rats (8) each. Groups A, B, C, D, E, F, G, H, constituted the test groups whereas group I served as the control group. The rats were allowed to acclimatize for three weeks and weighed before being fed for 8 weeks with feed pellets made by mixing the test substanc...