Quantifying Genome-Editing Outcomes at Endogenous Loci with SMRT Sequencing
Abstract
Targeted genome editing with engineered nucleases has transformed the ability to introduce precise sequence modifications at almost any site within the genome. A major obstacle to probing the efficiency and consequences of genome editing is that no existing method enables the frequency of different editing events to be simultaneously measured across a cell population at any endogenous genomic locus. We have developed a method for quantifying...
Paper Details
Title
Quantifying Genome-Editing Outcomes at Endogenous Loci with SMRT Sequencing
Published Date
Apr 1, 2014
Journal
Volume
7
Issue
1
Pages
293 - 305
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History