Elaidic acid sustains LPS and TNF-α induced ICAM-1 and VCAM-I expression on human bone marrow endothelial cells (HBMEC)

Elaidic acid, the predominant trans-fatty acid in industrially hydrogenated oils, exists on high levels in Iranian hydrogenated oils and margarines. This study was undertaken to investigate the effect of elaidic acid and its cis-counterpart oleic acid on expression of ICAM-1 and VCAM-1 on human bone marrow endothelial cells (HBMECs). HBMEC were pre-treated with TNF-α or LPS for induction of the adhesion molecules expression, and then treated...