Dietary Fat and Coronary Heart Disease: Summary of Evidence from Prospective Cohort and Randomised Controlled Trials

Countries Study also demonstrated strong associations between mean intakes of SFA and mean levels of serum total cholesterol [Keys, 1980]. The study prompted the ‘diet heart’ hypothesis that high intakes of SFA and cholesterol and low intakes of polyunsaturated fats (PUFA) increase the level of total cholesterol and ultimately result in the development of CHD. Indeed, the early results of the Seven Countries Study prompted an explosion of...