Low Molecular Weight Poly(ethylene glycol) as an Environmentally Benign Solvent for Pharmaceutical Crystallization and Precipitation

Low molecular weight poly(ethylene glycol) (PEG300) is examined as a possible environmentally benign replacement solvent for volatile organic solvents commonly used in crystallization and precipitation operations in pharmaceutical processing. It is shown to have solvating power comparable in magnitude to that of 2-propanol or methanol for model compounds including ibuprofen, salicylic acid, and amino acids. UNIFAC can be used to predict solvent...