Match!

Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis

Published on Jul 3, 2007in Diabetologia7.11
· DOI :10.1007/s00125-007-0708-y
Tracey McLaughlin40
Estimated H-index: 40
(Stanford University),
Arthur Sherman45
Estimated H-index: 45
(NIH: National Institutes of Health)
+ 5 AuthorsSamuel W. Cushman55
Estimated H-index: 55
(NIH: National Institutes of Health)
Cite
Abstract
Aims/hypothesis The biological mechanism by which obesity predisposes to insulin resistance is unclear. One hypothesis is that larger adipose cells disturb metabolism via increased lipolysis. While studies have demonstrated that cell size increases in proportion to BMI, it has not been clearly shown that adipose cell size, independent of BMI, is associated with insulin resistance. The aim of this study was to test this widely held assumption by comparing adipose cell size distribution in 28 equally obese, otherwise healthy individuals who represented extreme ends of the spectrum of insulin sensitivity, as defined by the modified insulin suppression test.
  • References (43)
  • Citations (213)
Cite
References43
Newest
Published on Apr 7, 2006in Journal of Biological Chemistry
Birgit Gustafson19
Estimated H-index: 19
,
Ulf Smith83
Estimated H-index: 83
Abstract Obesity with enlarged fat cells is associated with high local concentrations of interleukin-6 (IL-6) and tumor necrosis factor α (TNFα) in the adipose tissue. We examined the effects of this inflammatory state on 3T3-L1 preadipocyte development and differentiation to mature adipose cells. Both IL-6 and TNFα impaired the normal differentiation pattern and lipid accumulation. However, IL-6 allowed a normal early induction of differentiation with inhibition of Wnt10b and Pref-1, whereas ex...
Published on May 1, 2005in Hypertension7.02
David B. Savage3
Estimated H-index: 3
(Yale University),
Kitt Falk Petersen64
Estimated H-index: 64
(Yale University),
Gerald I. Shulman142
Estimated H-index: 142
(Yale University)
Insulin resistance is a major player in the pathogenesis of the metabolic syndrome and type 2 diabetes, and yet, the mechanisms responsible for it remain poorly understood. Magnetic resonance spectroscopy studies in humans suggest that a defect in insulin-stimulated glucose transport in skeletal muscle is the primary metabolic abnormality in insulin-resistant type 2 diabetics. Fatty acids appear to cause this defect in glucose transport by inhibiting insulin-stimulated tyrosine phosphorylation o...
Published on Dec 1, 2004in International Journal of Obesity4.51
Leonie K. Heilbronn37
Estimated H-index: 37
(Pennington Biomedical Research Center),
S R Smith10
Estimated H-index: 10
(Pennington Biomedical Research Center),
Eric Ravussin99
Estimated H-index: 99
(Pennington Biomedical Research Center)
Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
Published on Aug 1, 2004in Antiviral Therapy2.31
Jan1
Estimated H-index: 1
,
Pascale Cervera19
Estimated H-index: 19
+ 9 AuthorsAnne Lombès43
Estimated H-index: 43
Objective: To achieve a better understand of the pathophysiology of HIV-related lipoatrophy, we compared the mRNA expression of adipocytokines in fat samples from patients and healthy HIV-seronegative controls together with fat morphology and we studied the relationship between changes in fat morphology, adipocytokine expression, markers of adipose tissue differentiation and whole body insulin sensitivity. Design: Cross-sectional analytical study. Subjects and methods: The mRNA expression of adi...
Published on Jul 1, 2004in Diabetes Care15.27
Iwona Bogacka8
Estimated H-index: 8
,
Hui Xie20
Estimated H-index: 20
+ 1 AuthorsSteven R. Smith71
Estimated H-index: 71
OBJECTIVE —Pioglitazone is a member of the thiazolidinediones (TZDs), insulin-sensitizing agents used to treat type 2 diabetes. The aim of this study was to define the effect of pioglitazone on the expression of genes related to carbohydrate and lipid metabolism in subcutaneous fat obtained from type 2 diabetic patients. RESEARCH DESIGN AND METHODS —Forty-eight volunteers with type 2 diabetes were divided into two groups treated for 12 weeks with placebo or pioglitazone (30 mg/day). The expressi...
Published on May 1, 2004in Biochemical and Biophysical Research Communications2.71
Xiaolin Yang4
Estimated H-index: 4
(University of Gothenburg),
Per-Anders Jansson42
Estimated H-index: 42
(University of Gothenburg)
+ 6 AuthorsUlf Smith83
Estimated H-index: 83
(University of Gothenburg)
Abstract To elucidate the roles of adipose tissue and skeletal muscle in the early development of insulin resistance, we characterized gene expression profiles of isolated adipose cells and skeletal muscle of non-diabetic insulin-resistant first-degree relatives of type 2 diabetic patients using oligonucleotide microarrays. About 600 genes and expressed sequence tags, which displayed a gene expression pattern of cell proliferation, were differentially expressed in the adipose cells. The differen...
Published on Apr 1, 2004in Metabolism-clinical and Experimental6.51
Tracey McLaughlin40
Estimated H-index: 40
(Stanford University),
Gregory Allison1
Estimated H-index: 1
(Stanford University)
+ 2 AuthorsGerald M. Reaven113
Estimated H-index: 113
(Stanford University)
Abstract Obese individuals tend to be both insulin resistant and at increased risk to develop cardiovascular disease (CVD). Given the increased prevalence of obesity in the US population, we thought it important to define the relationship between degree of obesity and insulin-mediated glucose disposal in the population at large, as well as the relationship between obesity, insulin resistance, and CVD risk in these individuals. To do this we quantified insulin-mediated glucose disposal in 465 hea...
Published on Mar 1, 2004in Diabetes7.20
Fahim Abbasi47
Estimated H-index: 47
,
James Chu18
Estimated H-index: 18
+ 4 AuthorsPeter D. Reaven49
Estimated H-index: 49
Insulin resistance and obesity are both associated with lower plasma adiponectin concentrations. Since insulin resistance and obesity are related, the extent to which the association of adiponectin with insulin resistance is dependent on its relationship with obesity is unclear. To address this issue, fasting plasma adiponectin concentrations were measured in 60 nondiabetic subjects, stratified into four equal groups on the basis of both their degree of adiposity and insulin resistance. Insulin ...
Published on Jun 1, 2003in Metabolism-clinical and Experimental6.51
Guenther Boden1
Estimated H-index: 1
(TU: Temple University),
Peter Ying Kay Cheung1
Estimated H-index: 1
(TU: Temple University)
+ 1 AuthorsSusan K. Fried49
Estimated H-index: 49
(TU: Temple University)
Abstract The current study aimed to compare the effects of treatment (2 months) with thiazolidinediones (TZDs) and placebo on glucose and fat metabolism in patients with type 2 diabetes (T2DM) in a crossover design. Eight patients received placebo (2 months) followed by TZD (2 months). Two-stage (1.5 and 6.0 pmol/kg min) hyperinsulinemic-euglycemic clamps were performed in all 8 patients pre- and post-placebo and post-TZD (post-placebo = pre-TZD). We determined rates of glucose disappearance (G ...
Published on Dec 3, 2002in Circulation23.05
Tracey McLaughlin40
Estimated H-index: 40
,
Fahim Abbasi47
Estimated H-index: 47
+ 4 AuthorsPeter D. Reaven49
Estimated H-index: 49
Background— Plasma C-reactive protein (CRP) concentrations are increased in obese and/or hyperinsulinemic individuals. The goal of this study was to determine if the relation between insulin resistance and CRP was independent of obesity. Methods and Results— Plasma CRP concentrations were measured before and after 3 months of calorie restriction in 38 healthy, obese women. Steady-state plasma glucose (SSPG) concentration during a 180-minute infusion of octreotide, glucose, and insulin was used t...
Cited By213
Newest
Published on Jun 1, 2019in Molecular Aspects of Medicine8.31
Joseph D. White1
Estimated H-index: 1
(The Ohio State University Wexner Medical Center),
Revati S. Dewal2
Estimated H-index: 2
(The Ohio State University Wexner Medical Center),
Kristin I. Stanford16
Estimated H-index: 16
(The Ohio State University Wexner Medical Center)
Abstract Obesity is a disease that results from an imbalance between energy intake and energy expenditure. Brown adipose tissue (BAT) is a potential therapeutic target to improve the comorbidities associated with obesity due to its inherent thermogenic capacity and its ability to improve glucose metabolism. Multiple studies have shown that activation of BAT using either pharmacological treatments or cold exposure had an acute effect to increase metabolic function and reduce adiposity. Recent pre...
Published in Cardiovascular Pathology1.76
H. Aitken-Buck (University of Otago), Aram A Babakr (University of Otago)+ -3 AuthorsRegis R. Lamberts14
Estimated H-index: 14
(University of Otago)
Abstract Background Epicardial adipose tissue (EAT) deposition has a strong association with aspects of metabolic dysfunction, including obesity. The size of the EAT adipocytes in relation to obesity, however, has rarely been researched. Therefore, to contextualise EAT within the broader framework of pathophysiological adipocyte size changes in obesity, we aimed to determine whether EAT adipocyte size is associated with body mass index (BMI). Methods During routine post-mortem examination, adipo...
Published on Jul 11, 2019in Medical Sciences
Rodolfo C. Cardoso11
Estimated H-index: 11
,
Vasantha Padmanabhan52
Estimated H-index: 52
Polycystic ovary syndrome (PCOS) is a complex disorder that results from a combination of multiple factors, including genetic, epigenetic, and environmental influences. Evidence from clinical and preclinical studies indicates that elevated intrauterine androgen levels increase the susceptibility of the female offspring to develop the PCOS phenotype. Additionally, early postnatal endocrine and metabolic imbalances may act as a “second-hit”, which, through activational effects, might unmask or amp...
Published on Jul 5, 2019in Obesity Surgery3.60
Adriana Florinela Cătoi3
Estimated H-index: 3
,
Luca Busetto37
Estimated H-index: 37
(UNIPD: University of Padua)
A peculiar category of persons with obesity lacking common metabolic disturbances has been depicted and termed as metabolically healthy obesity (MHO). Yet, although MHO patients are free of obesity-associated complications, they might not be entirely precluded from developing cardio-metabolic disorders. Among patients with morbid obesity (MO) who are referred to bariatric surgery, a subset of metabolically healthy MO (MHMO) has been identified and the question arises if these patients would bene...
Published on Jul 1, 2019in Matrix Biology6.99
Rachel Blomberg1
Estimated H-index: 1
,
Daniel P. Beiting20
Estimated H-index: 20
+ 1 AuthorsEllen Puré36
Estimated H-index: 36
Published on Jul 1, 2019in EBioMedicine
Nanfei Yang3
Estimated H-index: 3
(NU: Nanjing University),
Qing Tang (NU: Nanjing University)+ 8 AuthorsHongbin Sun (CPU: China Pharmaceutical University)
Abstract Background Obesity leads to the chronic inflammation in the whole body and triggers the macrophage polarization to the pro-inflammatory phenotype. Targeting macrophage polarization provides a promising therapeutic strategy for obesity-related metabolic disorders and inflammation. Here, we show that SO1989, a derivative of natural occurring compound oleanolic acid, restores the balance between M1-polarized and M2-polarized macrophages in high fat diets (HFD)-induced obese mice resulting ...
Published on Aug 20, 2018in International Journal of Obesity4.51
Candice Allister-Price (UC Davis: University of California, Davis), Colleen M. Craig5
Estimated H-index: 5
(Stanford University)
+ 2 AuthorsTracey McLaughlin40
Estimated H-index: 40
(Stanford University)
African-American women have the greatest prevalence of obesity in the United States, and higher rates of type 2 diabetes than Caucasian women, yet paradoxically lower plasma triglycerides (TG), visceral fat and intrahepatic fat, and higher high-density lipoprotein (HDL)-cholesterol. Visceral fat has not been evaluated against insulin resistance in African-American women, and TG/HDL-cholesterol has been criticized as a poor biomarker for insulin resistance in mixed-sex African-American population...
Published on Jun 26, 2019in Journal of Toxicology and Environmental Health2.65
Lior Hassan (BGU: Ben-Gurion University of the Negev), Tal Pecht5
Estimated H-index: 5
(BGU: Ben-Gurion University of the Negev)
+ 5 AuthorsVictor Novack30
Estimated H-index: 30
(BGU: Ben-Gurion University of the Negev)
ABSTRACTThe effects of particulate matter (PM) air pollution on adipose tissue have mainly been studied in animal models. The aim of this study was to examine the potential associations between PM exposure and 25 cellular markers in human omental (OM) and subcutaneous (SC) adipose tissue. The PM exposure assessments for both PM2.5 (PM <2.5 μm in diameter) and PM10 (<10 μm) were based upon a novel hybrid satellite-based spatio-temporally resolved model. We calculated the PM exposure above the bac...
Published on Mar 1, 2019in Metabolism-clinical and Experimental6.51
Carla Iacobini25
Estimated H-index: 25
(Sapienza University of Rome),
Giuseppe Pugliese45
Estimated H-index: 45
(Sapienza University of Rome)
+ 2 AuthorsStefano Menini32
Estimated H-index: 32
(Sapienza University of Rome)
Abstract Obesity-related disease complications reduce life quality and expectancy and increase health-care costs. Some studies have suggested that obesity not always entails metabolic abnormalities and increased risk of cardiometabolic complications. Because of the lack of universally accepted criteria to identify metabolically healthy obesity (MHO), its prevalence varies widely among studies. Moreover, the prognostic value of MHO is hotly debated, mainly because it likely shifts gradually towar...