Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells

Volume: 14, Issue: 15, Pages: 2503 - 2510
Published: Dec 1, 2000
Abstract
Oxidized/cross-linked intracellular protein materials, known as ceroid pigment, age pigment, or lipofuscin, accumulate in postmitotic tissues. It is unclear, however, whether diminishing proteolytic capacities play a role in the accumulation of such oxidized intracellular proteins. Previous studies revealed that the proteasome is responsible for the degradation of most oxidized soluble cytoplasmic and nuclear proteins and, we propose, for the...
Paper Details
Title
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells
Published Date
Dec 1, 2000
Volume
14
Issue
15
Pages
2503 - 2510
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