Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway
Abstract
Non-homologous end joining (NHEJ) is a major pathway to repair DNA double-strand breaks (DSBs), which can display different types of broken ends. However, it is unclear how NHEJ factors organize to repair diverse types of DNA breaks. Here, through systematic analysis of the human NHEJ factor interactome, we identify PAXX as a direct interactor of Ku. The crystal structure of PAXX is similar to those of XRCC4 and XLF. Importantly, PAXX-deficient...
Paper Details
Title
Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway
Published Date
Feb 11, 2015
Journal
Volume
6
Issue
1
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