Toll-like receptor signaling in parasitic infections

The essential role played by Toll-like receptors (TLRs) during parasitic infections, as a part of the innate immune response, has gained much attention. TLR-induced signaling pathways can eradicate invading pathogens. However, uncontrolled activation of TLR leads to tissue damage. Therefore, negative regulation of TLRs results in diminished pro-inflammatory cytokine production and limits excessive pathology. This review outlines the interplay...