Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases.
Abstract
Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups. For instance, S-nitrosylation regulates enzymatic activity of target proteins via inhibition of active site cysteine residues or via allosteric regulation of protein structure. During normal brain function, protein S-nitrosylation serves as an...
Paper Details
Title
Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases.
Published Date
Dec 1, 2015
Journal
Volume
84
Pages
99 - 108
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