In vitro V(D)J recombination: Signal joint formation
Volume: 93, Issue: 24, Pages: 14008 - 14013
Published: Nov 26, 1996
Abstract
The first step of V(D)J recombination, specific cleavage at the recombination signal sequence (RSS), can be carried out by the recombination activating proteins RAG1 and RAG2. In vivo , the cleaved coding and signal ends must be rejoined to generate functional antigen receptors and maintain chromosomal integrity. We have investigated signal joint formation using deletion and inversion substrates in a cell free system. RAG1 and RAG2 alone or in...
Paper Details
Title
In vitro V(D)J recombination: Signal joint formation
Published Date
Nov 26, 1996
Volume
93
Issue
24
Pages
14008 - 14013
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