Loss of mPer2 increases plasma insulin levels by enhanced glucose‐stimulated insulin secretion and impaired insulin clearance in mice
Abstract
The existence of peripheral oscillators has been shown, and they are critically important for organizing the metabolism of the whole body. Here we show that mice deficient in mPer2 markedly increase circulatory levels of insulin compared with wild type mice. Insulin secretion was more effectively stimulated by glucose, and alloxan, a glucose analogue, induced more severe hyperglycemia in mPer2-deficient mice. Hepatic insulin degrading enzyme...
Paper Details
Title
Loss of mPer2 increases plasma insulin levels by enhanced glucose‐stimulated insulin secretion and impaired insulin clearance in mice
Published Date
Apr 5, 2012
Journal
Volume
586
Issue
9
Pages
1306 - 1311
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