Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress.

Volume: 400, Issue: 3, Pages: 511 - 520
Published: Dec 15, 2006
Abstract
Hyperphosphorylated tau proteins accumulate in the paired helical filaments of neurofibrillary tangles seen in such tauopathies as Alzheimer's disease. In the present paper we show that tau turnover is dependent on degradation by the proteasome (inhibited by MG132) in HT22 neuronal cells. Recombinant human tau was rapidly degraded by the 20 S proteasome in vitro, but tau phosphorylation by GSK3beta (glycogen synthase kinase 3beta) significantly...
Paper Details
Title
Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress.
Published Date
Dec 15, 2006
Volume
400
Issue
3
Pages
511 - 520
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