Soluble Guanylate Cyclase as a Novel Treatment Target for Osteoporosis
Abstract
Osteoporosis is a major health problem leading to fractures that cause substantial morbidity and mortality. Current osteoporosis therapies have significant drawbacks, creating a need for novel bone-anabolic agents. We previously showed that the nitric oxide/cyclic GMP (cGMP)/protein kinase G pathway mediates some of the anabolic effects of estrogens and mechanical stimulation in osteoblasts and osteocytes, leading us to hypothesize that...
Paper Details
Title
Soluble Guanylate Cyclase as a Novel Treatment Target for Osteoporosis
Published Date
Dec 1, 2014
Journal
Volume
155
Issue
12
Pages
4720 - 4730
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