Large conserved domains of low DNA methylation maintained by Dnmt3a
Abstract
Gains and losses in DNA methylation are prominent features of mammalian cell types. To gain insight into the mechanisms that promote shifts in DNA methylation and contribute to changes in cell fate, including malignant transformation, we performed genome-wide mapping of 5-methylcytosine and 5-hydroxymethylcytosine in purified mouse hematopoietic stem cells. We discovered extended regions of low methylation (canyons) that span conserved domains...
Paper Details
Title
Large conserved domains of low DNA methylation maintained by Dnmt3a
Published Date
Nov 24, 2013
Journal
Volume
46
Issue
1
Pages
17 - 23
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