Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Abstract
Alzheimer's disease is characterized by amyloid-beta plaques, neurofibrillary tangles, gliosis, and neuronal loss. Solanezumab, a humanized monoclonal antibody, preferentially binds soluble forms of amyloid and in preclinical studies promoted its clearance from the brain.In two phase 3, double-blind trials (EXPEDITION 1 and EXPEDITION 2), we randomly assigned 1012 and 1040 patients, respectively, with mild-to-moderate Alzheimer's disease to...
Paper Details
Title
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Published Date
Jan 23, 2014
Volume
370
Issue
4
Pages
311 - 321
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