The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Abstract
Many tumour cells express the M2 form of pyruvate kinase rather than the usual M1 form. PKM2 is now shown to promote tumorigenesis and switch the cellular metabolism to increased lactate production and reduced oxygen consumption, recapitulating key aspects of the Warburg...
Paper Details
Title
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Published Date
Mar 1, 2008
Journal
Volume
452
Issue
7184
Pages
230 - 233
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