The action of selective CRAC channel blockers is affected by the Orai pore geometry
Abstract
As the molecular composition of calcium-release activated calcium (CRAC) channels has been unknown for two decades, elucidation of selective inhibitors has been considerably hampered. By the identification of the two key components of CRAC channels, STIM1 and Orai1 have emerged as promising targets for CRAC blockers. The aim of this study was to thoroughly characterize the effects of two selective CRAC channel blockers on currents derived from...
Paper Details
Title
The action of selective CRAC channel blockers is affected by the Orai pore geometry
Published Date
Feb 1, 2013
Journal
Volume
53
Issue
2
Pages
139 - 151
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Notes
History