Deciphering the emerging role of SUMO conjugation in the hypoxia-signaling cascade
Abstract
By driving the primary transcriptional response, the hypoxia inducible factor (HIF) is a master player of the hypoxia-signaling cascade, activation of which is essential to maintain oxygen homeostasis. HIF is formed by the interaction of a constitutive HIF-1β subunit with a HIF-α subunit tightly regulated through the concerted action of the prolyl hydroxylase domain containing proteins (PHDs) and factor inhibiting HIF. In well-oxygenated cells,...
Paper Details
Title
Deciphering the emerging role of SUMO conjugation in the hypoxia-signaling cascade
Published Date
Feb 28, 2013
Journal
Volume
394
Issue
4
Pages
459 - 469
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Notes
History