T‐type Ca2+ current as a trigger for Ca2+ release from the sarcoplasmic reticulum in guinea‐pig ventricular myocytes
Abstract
1. We have investigated whether Ca2+ entry through T-type Ca2+ channels participates in triggering Ca2+ release from the sarcoplasmic reticulum (SR) in single guinea-pig ventricular myocytes (whole-cell voltage clamp, K5fura-2 as [Ca2+]i indicator; all monovalent cations replaced by impermeant ions to record uncontaminated Ca2+ currents; T = 23 or 36 degrees C). 2. T-type Ca2+ currents were elicited from a holding potential of -90 mV during...
Paper Details
Title
T‐type Ca2+ current as a trigger for Ca2+ release from the sarcoplasmic reticulum in guinea‐pig ventricular myocytes
Published Date
Apr 1, 1998
Journal
Volume
508
Issue
2
Pages
439 - 451
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