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Group VA Poly(amine esters) Containing the Antibacterial Ampicillin

Published on May 1, 2015in Journal of Inorganic and Organometallic Polymers and Materials 1.64
· DOI :10.1007/s10904-014-0050-z
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 2 AuthorsMohammed H. Al-huniti4
Estimated H-index: 4
(FAU: Florida Atlantic University)
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Abstract
Polyester amines were formed from the reaction of the salt of ampicillin with triphenyarsenic, triphenylantimony, and triphenylbismuth dihalides employing the interfacial polycondensation reaction. IR shows the formation of M–OC=O and M–N bands consistent with the proposed polymer formation. Further, IR results are consistent with the repeat units connecting in a somewhat random manner about the metal atom. MALDI MS results give ion fragments to one and two units in length that are consistent with the proposed structure. Polymers were tested for their ability to inhibit the growth of a number of cancer cell lines including prostate, colon, breast (two cell lines) and pancreatic (two cell lines) cancer cell lines with all of the polymers showing ability to inhibit several of the cancer cell lines.
  • References (46)
  • Citations (2)
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References46
Newest
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Alicia Morrison2
Estimated H-index: 2
(FAU: Florida Atlantic University)
+ 2 AuthorsNancy T. Trang5
Estimated H-index: 5
(UTA: University of Texas at Arlington)
Organotin polyesters were synthesized from the interfacial condensation of organotin dihalides and salts of 3,5-pyridinedicarboxylic acid. The polymers are synthesized in moderate to high yields and are moderate to high polymers. MALDI MS, IR spectral, and NMR spectral results are consistent with the proposed structure. The Sn–O stretching band is found at about 1,028 cm−1. Infrared spectra are consistent with majority of the products having a non-bridged structure about the tin. All of the poly...
7 Citations Source Cite
Published on Aug 15, 2006
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
Introduction to Polymers History of Polymers Why Polymers? Today's Marketplace Environmental Assessment Managing Sustainability Polymer Structure (Morphology) Stereochemistry of Polymers Molecular Interactions Polymer Crystals Amorphous Bulk State Polymer Structure-Property Relationships Crystalline and Amorphous Combinations Cross-Linking Molecular Weight of Polymers Introduction Solubility Average Molecular Weight Values Fractionation of Polydisperse Systems Chromatography Colligative Molecula...
85 Citations
Published on Nov 1, 2012in Cell and Tissue Research 3.36
Andy C. H. Chen3
Estimated H-index: 3
(HKU: University of Hong Kong),
Yin-Lau Lee12
Estimated H-index: 12
(HKU: University of Hong Kong)
+ 7 AuthorsWilliam S.B. Yeung43
Estimated H-index: 43
(HKU: University of Hong Kong)
Human embryonic stem cells (hESCs) have great potential for regenerative medicine as they have self-regenerative and pluripotent properties. Feeder cells or their conditioned medium are required for the maintenance of hESC in the undifferentiated state. Feeder cells have been postulated to produce growth factors and extracellular molecules for maintaining hESC in culture. The present study has aimed at identifying these molecules. The gene expression of supportive feeder cells, namely human fore...
9 Citations Source Cite
Published on Aug 1, 2012in Toxicology and Applied Pharmacology 3.58
Maciej Stępnik15
Estimated H-index: 15
(Nofer Institute of Occupational Medicine),
Joanna Arkusz10
Estimated H-index: 10
(Nofer Institute of Occupational Medicine)
+ 7 AuthorsKonrad Rydzynski17
Estimated H-index: 17
(Nofer Institute of Occupational Medicine)
Abstract The potential toxic effects in murine (3T3-L1) and human (WI-38) fibroblast cell lines of commercially available silica nanoparticles (NPs), Ludox CL (nominal size 21 nm) and CL-X (nominal size of 30 nm) were investigated with particular attention to the effect over long exposure times (the tests were run after 72 h exposure up to 7 days). These two formulations differed in physico-chemical properties and showed different stabilities in the cell culture medium used for the experiments. ...
12 Citations Source Cite
Published on May 27, 2011in Materials 2.97
Michael R. Roner19
Estimated H-index: 19
,
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
+ 1 AuthorsGirish Barot11
Estimated H-index: 11
(BU: Boston University)
Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very ...
17 Citations Source Cite
Published on Apr 15, 2011in Materials 2.97
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
+ 1 AuthorsGirish Barot11
Estimated H-index: 11
(BU: Boston University)
The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less ...
23 Citations Source Cite
Published on Jan 1, 2010in Molecular Cancer 10.68
Mei Shi13
Estimated H-index: 13
(SDU: Shandong University),
Hong-Na Wang2
Estimated H-index: 2
(SDU: Shandong University)
+ 4 AuthorsYu-Zhong Zhang9
Estimated H-index: 9
(SDU: Shandong University)
Background Hepatocellular carcinoma (HCC) is one of the most common cancers in the world which is highly chemoresistant to currently available chemotherapeutic agents. Thus, novel therapeutic targets are needed to be sought for the successful treatment of HCC. Peptaibols, a family of peptides synthesized non-ribosomally by the Trichoderma species and other fungi, exhibit antibiotic activities against bacteria and fungi. Few studies recently showed that peptaibols exerted cytotoxicity toward huma...
65 Citations Source Cite
Published on Oct 21, 2009in Materials 2.97
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synth...
24 Citations Source Cite
Published on Jan 1, 2009in European Journal of Medicinal Chemistry 4.83
Karlo Wittine7
Estimated H-index: 7
(University of Zagreb),
Krešimir Benci4
Estimated H-index: 4
(University of Zagreb)
+ 9 AuthorsRobert Snoeck54
Estimated H-index: 54
(Rega Institute for Medical Research)
The target phosphoramidates 5a-e were prepared in one step from 3-hydroxypropyl derivatives 3a-e of nonsteroidal anti-inflammatory drugs (fenoprofen, ketoprofen, ibuprofen, indomethacin, diclofenac). The products 3a-e and 5a-e were evaluated for their cytostatic and antiviral activity against malignant tumour cell lines and normal human fibroblasts (WI38). All phosphoramidate derivatives 5a-e possess significantly greater inhibitory activities than the corresponding 3-hydroxypropyl derivatives 3...
28 Citations Source Cite
Heguo Zhu13
Estimated H-index: 13
(Nanjing University of Science and Technology),
Hengzhi Wang5
Estimated H-index: 5
(Nanjing University of Science and Technology)
+ 2 AuthorsYunzhan Yuan1
Estimated H-index: 1
(Nanjing University of Science and Technology)
Abstract This paper investigates the microstructure, mechanical properties and fracture mechanism of composites fabricated by the exothermic dispersion method in the Al–TiO 2 –B 2 O 3 reaction system. When the B 2 O 3 /TiO 2 mole ratio is zero, the reinforcements of the composites are composed of α-Al 2 O 3 and Al 3 Ti. The α-Al 2 O 3 particulates are segregated at matrix boundaries and cannot enter the aluminum matrix grains due to poor wetting with the matrix and the Al 3 Ti rods distribute un...
31 Citations Source Cite
Cited By2
Newest
Published on Oct 1, 2018in Macromolecular Rapid Communications 4.08
Joji Tanaka5
Estimated H-index: 5
(Warw.: University of Warwick),
Thomas P. Davis82
Estimated H-index: 82
(Warw.: University of Warwick),
Paul Wilson34
Estimated H-index: 34
(Warw.: University of Warwick)
2 Citations Source Cite
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 5 AuthorsPaul Slawek2
Estimated H-index: 2
(FAU: Florida Atlantic University)
Polyesters were rapidly synthesized employing interfacial polymerization from reaction of the salt of camphoric acid with Group VA (Group 15) triphenylmetallic dihalides. Yields range from 25 to 46 percent with chain lengths about 250. Infrared spectroscopy shows the formation of two new bands one assigned to the symmetrical M–O stretching and the second assigned to the asymmetrical M–O stretching. The bridging structure about the metal atom increases as the metal atom size increases. MALDI MS a...
2 Citations Source Cite