Group VA Poly(amine esters) Containing the Antibacterial Ampicillin

Published on May 1, 2015in Journal of Inorganic and Organometallic Polymers and Materials 1.75
· DOI :10.1007/s10904-014-0050-z
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 2 AuthorsMohammed H. Al-huniti4
Estimated H-index: 4
(Florida Atlantic University)
Abstract
Polyester amines were formed from the reaction of the salt of ampicillin with triphenyarsenic, triphenylantimony, and triphenylbismuth dihalides employing the interfacial polycondensation reaction. IR shows the formation of M–OC=O and M–N bands consistent with the proposed polymer formation. Further, IR results are consistent with the repeat units connecting in a somewhat random manner about the metal atom. MALDI MS results give ion fragments to one and two units in length that are consistent with the proposed structure. Polymers were tested for their ability to inhibit the growth of a number of cancer cell lines including prostate, colon, breast (two cell lines) and pancreatic (two cell lines) cancer cell lines with all of the polymers showing ability to inhibit several of the cancer cell lines.
  • References (46)
  • Citations (2)
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References46
Published on Aug 15, 2006
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University)
Introduction to Polymers History of Polymers Why Polymers? Today's Marketplace Environmental Assessment Managing Sustainability Polymer Structure (Morphology) Stereochemistry of Polymers Molecular Interactions Polymer Crystals Amorphous Bulk State Polymer Structure-Property Relationships Crystalline and Amorphous Combinations Cross-Linking Molecular Weight of Polymers Introduction Solubility Average Molecular Weight Values Fractionation of Polydisperse Systems Chromatography Colligative Molecula...
81 Citations
Published on Sep 5, 2003
Alaa S. Abd-El-Aziz22
Estimated H-index: 22
,
Charles E. Carraher23
Estimated H-index: 23
+ 2 AuthorsMartel Zeldin6
Estimated H-index: 6
128 Citations Source Cite
Published on Jan 1, 1984
Lon J. Mathias1
Estimated H-index: 1
,
Charles E. Carraher1
Estimated H-index: 1
51 Citations Source Cite
Published on Jan 1, 1988in Macromolecular Chemistry and Physics 2.49
Severian Dumitriu8
Estimated H-index: 8
,
Marcel Popa18
Estimated H-index: 18
The coupling reaction of ampicillin with the polysaccharide xanthane in DMSO, using dicyclohexylcarbodiimide as activator, was studied. To find the conditions for maximum yield a regression equation was established, describing the dependence of the yield of coupling product on the reaction parameters (drug/support mole ratio, activator/support mole ratio and duration), starting from an experimental, centrated rotable complex, second order program. The coupling product was spectroscopically chara...
4 Citations Source Cite
Published on Dec 28, 1979in Angewandte Makromolekulare Chemie
Charles E. Carraher5
Estimated H-index: 5
(Wright State University),
Howard S. Blaxall2
Estimated H-index: 2
(University of South Dakota)
The synthesis of antimony polyesters occurs under quite specific conditions utilizing the interfacial technique. Reaction is second order with specific rate constants in the range of 10−1 to 101 1/mol·s. Molecular weight is independent of reaction time. Reaction rate increases as the reaction liquid phase volume increases. The products are oligomeric to polymeric with weight average molecular weights of 3 to 100 × 103. Many products exhibit low viscous drag compared with chain length. The produc...
14 Citations Source Cite
Published on Oct 15, 1988in Analytical Chemistry 6.04
Michael Karas68
Estimated H-index: 68
,
Franz Hillenkamp55
Estimated H-index: 55
In the following, the first results on ultraviolet laser desorption (UVLD) of bioorganic compounds in the mass range above 10000 daltons are reported. Strong molecular ion signals were registered by use of an organic matrix with strong absorption at the wavelength used for controlled energy deposition and soft desorption (7)
4,207 Citations Source Cite
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University),
Kenzo Morie1
Estimated H-index: 1
Organotin polyesters have been synthesized employing the classical interfacial polycondensation of organotin dihalides and the salt of 1,1′-ferrocenedicarboxylic acid. The products are oligomeric (DP = 5) to polymeric (DP = 220). The presence of new IR bands characteristic of formation of the Sn–O band are present. Ion fragments characteristic of the repeat unit and greater are found employing F MALDI MS.
11 Citations Source Cite
Published on Sep 1, 1981in Nature 41.58
M. Barber34
Estimated H-index: 34
(University of Manchester),
Robert S. Bordoli25
Estimated H-index: 25
(University of Manchester)
+ 1 AuthorsAndrew N. Tyler35
Estimated H-index: 35
(University of Manchester)
A new ion source for molecular structure determination of thermolabile and involatile compounds by mass spectrometry is presented together with some preliminary results from peptides, glycoside antibiotics, organometallics and vitamin B12 its coenzyme.
468 Citations Source Cite
Published on Jan 1, 1971in International Archives of Allergy and Immunology 2.44
H. Ottens1
Estimated H-index: 1
,
E. de Haan1
Estimated H-index: 1
,
C.H.J. Sengers1
Estimated H-index: 1
A search for high molecular residues in penicillin G was carried out using several recently described methods. By the membrane filtration method the protein content of a large number of batches of penicillin G, 6-APA (chemically prepared), and ampicillin was determined. Significantly lower protein values were found for these compounds than for microbiologically produced 6-APA and the ampicillin made from it. Purified macromolecular complexes of penicillin gave protein values in the membrane filt...
10 Citations Source Cite
Published on Oct 21, 2009in Materials 2.47
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synth...
24 Citations Source Cite
Cited By2
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 5 AuthorsPaul Slawek2
Estimated H-index: 2
(Florida Atlantic University)
Polyesters were rapidly synthesized employing interfacial polymerization from reaction of the salt of camphoric acid with Group VA (Group 15) triphenylmetallic dihalides. Yields range from 25 to 46 percent with chain lengths about 250. Infrared spectroscopy shows the formation of two new bands one assigned to the symmetrical M–O stretching and the second assigned to the asymmetrical M–O stretching. The bridging structure about the metal atom increases as the metal atom size increases. MALDI MS a...
2 Citations Source Cite
Published on Oct 1, 2018in Macromolecular Rapid Communications 4.44
Joji Tanaka4
Estimated H-index: 4
(University of Warwick),
Thomas P. Davis81
Estimated H-index: 81
(University of Warwick),
Paul Wilson35
Estimated H-index: 35
(University of Warwick)
2 Citations Source Cite