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Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents

Published on Mar 1, 2004in The Journal of Clinical Endocrinology and Metabolism5.61
· DOI :10.1210/jc.2003-031503
Catherine W. Yeckel13
Estimated H-index: 13
,
Ram Weiss33
Estimated H-index: 33
+ 5 AuthorsSonia Caprio65
Estimated H-index: 65
Cite
Abstract
Given the extreme increase in prediabetes, type 2 diabetes, and the potential for metabolic syndrome in obese youth, identifying simplified indexes for assessing stimulated insulin sensitivity is critical. The purpose of this study was validation of two surrogate indexes of insulin sensitivity determined from the oral glucose tolerance test (OGTT): the composite whole body insulin sensitivity index (WBISI) and the insulin sensitivity index (ISI). An obese population (aged 8–18 yr) of normal and impaired glucose tolerance individuals was studied. One group (n = 38) performed both the euglycemic-hyperinsulinemic clamp and OGTT for comparison of insulin sensitivity measurements as well as 1H-magnetic resonance spectroscopy estimates of intramyocellular lipid content. Another larger (n = 368) cohort participated only in an OGTT. Both the WBISI and ISI represented good estimates (r = 0.78 and 0.74; P < 0.0005) for clamp-derived insulin sensitivity (glucose disposed, M-value), respectively. In the large cohort,...
  • References (22)
  • Citations (260)
Cite
References22
Newest
Published on Sep 1, 2003in The Lancet59.10
Ram Weiss33
Estimated H-index: 33
(Yale University),
Sylvie Dufour15
Estimated H-index: 15
(HHMI: Howard Hughes Medical Institute)
+ 12 AuthorsFrancis Rife3
Estimated H-index: 3
(Yale University)
Summary Background Impaired glucose tolerance is common among obese adolescents, but the changes in insulin sensitivity and secretion that lead to this prediabetic state are unknown. We investigated whether altered partitioning of myocellular and abdominal fat relates to abnormalities in glucose homoeostasis in obese adolescents with prediabetes. Methods We studied 14 obese children with impaired glucose tolerance and 14 with normal glucose tolerance, of similar ages, sex distribution, and degre...
Published on Mar 1, 2003in The Journal of Clinical Endocrinology and Metabolism5.61
Supamai Soonthornpun11
Estimated H-index: 11
,
Worawong Setasuban10
Estimated H-index: 10
+ 3 AuthorsAlan Geater25
Estimated H-index: 25
(PSU: Prince of Songkla University)
The euglycemic hyperglycemic clamp is generally regarded as a reference method for assessing insulin sensitivity. However, this method is laborious and expensive. The oral glucose tolerance test (OGTT), the most commonly used method for evaluating whole body glucose tolerance, has often been used to assess insulin sensitivity. In the previous studies the correlation between the insulin sensitivity index (ISI) obtained from the OGTT (ISIOGTT) and those obtained from the glucose clamp (ISIClamp) m...
Published on Jan 1, 2003in Diabetologia7.11
Steven E. Kahn91
Estimated H-index: 91
(UW: University of Washington)
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes have been debated extensively. The concept that a feedback loop governs the interaction of the insulin-sensitive tissues and the beta cell as well as the elucidation of the hyperbolic relationship between insulin sensitivity and insulin secretion explains why insulin-resistant subjects exhibit markedly increased insulin responses while those who are insulin-sensitive have low resp...
Published on Dec 27, 2002in Journal of Biological Chemistry
Chunli Yu7
Estimated H-index: 7
(Garvan Institute of Medical Research),
Yan Chen9
Estimated H-index: 9
(Garvan Institute of Medical Research)
+ 11 AuthorsGregory J. Cooney53
Estimated H-index: 53
(Garvan Institute of Medical Research)
Abstract Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine the mechanism by which fatty acids mediate this effect, rats were infused with either a lipid emulsion (consisting mostly of 18:2 fatty acids) or glycerol. Intracellular C18:2 CoA increased in a time-dependent fashion, reaching an ∼6-fold elevation by 5 h, wh...
Published on Jul 1, 2002in Diabetic Medicine3.11
T. M. Wallace1
Estimated H-index: 1
,
D. R. Matthews1
Estimated H-index: 1
Background Insulin resistance exists when a normal concentration of insulin produces a less than normal biological response. The ability to measure insulin resistance is important in order to understand the aetiopathology of Type 2 diabetes, to examine the epidemiology and to assess the effects of intervention. Methods We assess and compare methods of measurement and have undertaken a literature review from 1966 to 2001. Results Quantitative estimates of insulin resistance can be obtained using ...
Published on Jul 1, 2002in Annual Review of Nutrition8.42
David E. Kelley79
Estimated H-index: 79
,
Bret H. Goodpaster80
Estimated H-index: 80
,
Len Storlien2
Estimated H-index: 2
▪ Abstract Skeletal muscle contains the majority of the body's glycogen stores and a similar amount of readily accessible energy as intramyocellular triglyceride (imTG). While a number of factors have been considered to contribute to the pathogenesis of insulin resistance (IR) in obesity and type 2 diabetes mellitus (DM), this review will focus on the potential role of skeletal muscle triglyceride content. In obesity and type 2 DM, there is an increased content of lipid within and around muscle ...
Published on Apr 1, 2002in Diabetes7.20
Ranjana Sinha2
Estimated H-index: 2
,
Sylvie Dufour56
Estimated H-index: 56
+ 7 AuthorsSonia Caprio65
Estimated H-index: 65
The metabolism and composition of skeletal muscle tissue is of special interest because it is a primary site of insulin action and plays a key role in the pathogenesis of insulin resistance. Intramyocellular (IMCL) triglyceride stores are an accessible form of energy that may decrease skeletal muscle glucose utilization, thereby contributing to impaired glucose metabolism. Because of the invasive nature of muscle biopsies, there is limited, if any, information about intramuscular lipid stores in...
Published on Mar 14, 2002in The New England Journal of Medicine70.67
Ranjana Sinha2
Estimated H-index: 2
,
Gene Fisch1
Estimated H-index: 1
+ 9 AuthorsSonia Caprio65
Estimated H-index: 65
Background Childhood obesity, epidemic in the United States, has been accompanied by an increase in the prevalence of type 2 diabetes among children and adolescents. We determined the prevalence of impaired glucose tolerance in a multiethnic cohort of 167 obese children and adolescents. Methods All subjects underwent a two-hour oral glucose-tolerance test (1.75 mg of glucose per kilogram of body weight), and glucose, insulin, and C-peptide levels were measured. Fasting levels of proinsulin were ...
Published on Mar 1, 2002in Diabetes Care15.27
Yoshinori Miyazaki20
Estimated H-index: 20
(University of Texas Health Science Center at San Antonio),
Masafumi Matsuda20
Estimated H-index: 20
(University of Texas Health Science Center at San Antonio),
Ralph A. DeFronzo134
Estimated H-index: 134
OBJECTIVE —To investigate the dose-response effects of pioglitazone on glycemic control, insulin sensitivity, and insulin secretion in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS —A total of 58 diet-treated patients with type 2 diabetes (aged 54 ±1 years; 34 men and 24 women; BMI 31.5± 0.6 kg/m 2 ) were randomly assigned to receive placebo ( n =11) or 7.5 mg ( n =13), 15 mg ( n =12), 30 mg ( n =11), or 45 mg ( n =11) of pioglitazone per day for 26 weeks. Before and after 26 weeks,...
Published on Jan 1, 2002in Diabetes, Obesity and Metabolism6.13
Gerald M. Reaven113
Estimated H-index: 113
(Stanford University)
Summary Recent evidence from the United Kingdom Prospective Diabetes Study convincingly demonstrates that good glycaemic control is difficult to achieve and, despite its positive impact on microvascular complications, is not sufficient to reduce the risk of coronary heart disease (CHD). Syndrome X—a cluster of abnormalities associated with resistance to insulin-mediated glucose uptake that have been implicated in accelerating atherogenesis—provides a useful clinical concept to prevent CHD in pat...
Cited By260
Newest
Published on Sep 9, 2019in International Journal of Molecular Sciences4.18
Alessia Di Costanzo5
Estimated H-index: 5
,
Lucia Pacifico31
Estimated H-index: 31
+ 6 AuthorsMarcello Arca36
Estimated H-index: 36
: Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of kidney disease in adults and children. However, it is uncertain whether this association is influenced by major NAFLD susceptibility genes. In a sample of 230 overweight/obese children, 105 with NAFLD (hepatic fat fraction ≥5% by magnetic resonance imaging) and 125 without NAFLD, rs738409 in PNPLA3, rs58542926 in TM6SF2, rs1260326 in GCKR, and rs641738 in MBOAT7 were genotyped. Abnormal kidney function was defined...
Richard D. Khusial (Mercer University), Catherine E. Cioffi1
Estimated H-index: 1
(Emory University)
+ 7 AuthorsBridget Pierpont20
Estimated H-index: 20
(Yale University)
Published on Dec 19, 2018in International Journal of Obesity4.51
Francesca Olivieri , Chiara Zusi2
Estimated H-index: 2
+ 5 AuthorsClaudio Maffeis36
Estimated H-index: 36
To assess whether combining glucose shape and 2-h glucose concentration during an oral glucose tolerance test (OGTT) may help identifying normal glucose tolerant obese children/adolescents with an impaired glucose tolerant (IGT)-like metabolic profile in term of insulin sensitivity (Matsuda index) and β-cell function (disposition index: DI). In total, 654 non-diabetic obese children/adolescents underwent a 2 h OGTT. The whole population was classified according to 2-hour plasma glucose ( 0.05). ...
Published on Jun 4, 2019in Frontiers in Endocrinology3.63
Veronica Maria Tagi , Cosimo Giannini21
Estimated H-index: 21
,
Francesco Chiarelli56
Estimated H-index: 56
Insulin resistance (IR) is a pathological condition strongly associated with obesity. However, corticosteroids or growth hormone therapy and genetic diseases may affect insulin sensitivity lifelong. In obese children and adolescents of any age there is an evident association between IR and an increased prevalence of type 2 diabetes (T2D) and other elements contributing to the metabolic syndrome, leading to a higher cardiovascular risk. Therefore, early diagnosis and interventions in the attempt ...
Published on May 1, 2019in Diabetes, Obesity and Metabolism6.13
Domenico Tricò7
Estimated H-index: 7
(UniPi: University of Pisa),
Alfonso Galderisi8
Estimated H-index: 8
(Yale University)
+ 2 AuthorsSonia Caprio65
Estimated H-index: 65
(Yale University)
Published on Apr 2, 2019in The Journal of Clinical Endocrinology and Metabolism5.61
Alfonso Galderisi8
Estimated H-index: 8
(Yale University),
Cosimo Giannini21
Estimated H-index: 21
(Yale University)
+ 1 AuthorsSonia Caprio65
Estimated H-index: 65
(Yale University)
Published on Apr 1, 2019in International Journal of Obesity4.51
Giuseppina Rosaria Umano4
Estimated H-index: 4
(Yale University),
Veronika Shabanova9
Estimated H-index: 9
(Yale University)
+ 6 AuthorsSonia Caprio65
Estimated H-index: 65
(Yale University)
The relative proportion of visceral fat (VAT) to subcutaneous fat (SAT) has been described as a major determinant of insulin resistance (IR). Our study sought to evaluate the effect of body fat distribution on glucose metabolism and intrahepatic fat content over time in a multiethnic cohort of obese adolescents. We examined markers of glucose metabolism by oral glucose tolerance test, and body fat distribution by abdominal MRI at baseline and after 19.2 ± 11.4 months in a cohort of 151 obese ado...
Published on Mar 1, 2019in Pediatric Diabetes3.35
Mélanie Henderson13
Estimated H-index: 13
(Centre Hospitalier Universitaire Sainte-Justine),
Andraea Van Hulst9
Estimated H-index: 9
(McGill University)
+ 2 AuthorsGilles Paradis49
Estimated H-index: 49
(McGill University)
Published on Dec 1, 2018in Diabetes, Obesity and Metabolism6.13
Domenico Tricò7
Estimated H-index: 7
(UniPi: University of Pisa),
Andrea Natali47
Estimated H-index: 47
(UniPi: University of Pisa)
+ 3 AuthorsSonia Caprio65
Estimated H-index: 65
(Yale University)
Published on Dec 1, 2018in Contemporary Clinical Trials2.28
Lauren B. Shomaker19
Estimated H-index: 19
(CSU: Colorado State University),
Lauren D. Gulley7
Estimated H-index: 7
(CSU: Colorado State University)
+ 9 AuthorsKenneth P. Wright43
Estimated H-index: 43
(CU: University of Colorado Boulder)
Abstract Background Depressive symptoms often manifest in adolescence and predict worsening insulin sensitivity, a key precursor in the path to β-cell failure and type 2 diabetes (T2D). Objective To assess the efficacy of a six-week cognitive-behavioral group versus six-week health education group for improving insulin sensitivity and preserving β-cell function in adolescent girls at-risk for T2D with depressive symptoms and evaluate mechanisms underlying the association between depression and i...
View next paperPrevalence of impaired glucose tolerance among children and adolescents with marked obesity.