Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer

Cancer Immunosurveillance Gone Bad? A subset of patients who develop scleroderma, a debilitating autoimmune disease, have an elevated risk of developing cancer. These patients harbor autoantibodies to RPC1, an RNA polymerase subunit encoded by the POLR3A gene. Joseph et al. (p. 152 , published online December 5; see the Perspective by Teng and Smyth ) explored whether the RPC1 autoantibodies target a “foreign” antigen derived from a mutated...